Results 21 to 30 of about 1,631,615 (310)

The assessment of researchers' competence in experimental procedures with laboratory animals: A three-step methodology to develop a global rating scale [PDF]

open access: yes, 2021
To conduct animal experiments, researchers must be competent to handle and perform interventions on living animals in compliance with regulations. Laboratory animal science training programs and licensing bodies therefore need to be able to reliably ...
Costa, MJ   +3 more
core   +1 more source

Amphibians as Laboratory Animals [PDF]

open access: yesILAR Journal, 1995
Scientists Center for Animal Welfare (Available from SCAW, Golden Triangle Building One, 7833 Walker Drive, Suite 340, Greenbelt, MD 20770. Tel: 301/345-3500; Fax: 301/345-3503). Scott WB, Crossman EJ. 1973. Freshwater Fish of Canada. Fisheries Research Board of Canada, Bulletin 184. Snodgrass MJ, Burke JD, Meetz GD. 1976.
openaire   +2 more sources

Development of a real-time loop-mediated isothermal amplification assay for detection of porcine circovirus 3

open access: yesBMC Veterinary Research, 2019
Background Porcine circovirus type 3 (PCV3) is an emerging circovirus species, that has been reported in major pig-raising countries including the United States, China, South Korea, Brazil, Spain, and Poland.
Huanan Wang   +13 more
doaj   +1 more source

Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody

open access: yesScientific Reports, 2021
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune responses to ICI
Ikumi Katano   +9 more
doaj   +1 more source

Identificationof a novel linear epitope on the porcine reproductive and respiratory syndrome virus nucleocapsid protein, as recognized by a specific monoclonal antibody

open access: yesFrontiers in Immunology, 2023
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most threatening pathogens of swine. The nucleocapsid (N) protein is the major structural protein of the virus and has been used as a PRRSV diagnostic antigen due ...
Yuening Cheng   +6 more
doaj   +1 more source

Isolation and characterization of Bordetella pseudohinzii in mice in China

open access: yesAnimal Models and Experimental Medicine, 2019
We report on the first detection and isolation of B. pseudohinzii (Bordetella pseudohinzii) in laboratory mice in China. Forty‐one B. pseudohinzii strains were isolated from 3094 mice in 33 different laboratory animal facilities in southern China.
Lei Ma   +8 more
doaj   +1 more source

Prediction of Compound Synthesis Accessibility Based on Reaction Knowledge Graph

open access: yesMolecules, 2022
With the increasing application of deep-learning-based generative models for de novo molecule design, the quantitative estimation of molecular synthetic accessibility (SA) has become a crucial factor for prioritizing the structures generated from ...
Baiqing Li, Hongming Chen
doaj   +1 more source

Laboratory animal allergy

open access: yesJournal of Allergy and Clinical Immunology, 1998
Approximately one third of laboratory animal workers have occupational allergy to animal danders, and a third of these have symptomatic asthma. Sensitization generally occurs with the first 3 years of employment, and risk factors include atopic background, as well as job description as it relates to the intensity of exposure.
R K, Bush, R A, Wood, P A, Eggleston
openaire   +2 more sources

Establishment and evaluation of a transgenic mouse model of arthritis induced by overexpressing human tumor necrosis factor alpha

open access: yesBiology Open, 2016
Tumor necrosis factor alpha (TNFα) plays a key role in the pathogenesis of rheumatoid arthritis (RA). Blockade of TNFα by monoclonal antibody has been widely used for the therapy of RA since the 1990s; however, its mechanism of efficacy, and potential ...
Ge Li   +6 more
doaj   +1 more source

Alternatives to Carbon Dioxide—Taking Responsibility for Humanely Ending the Life of Animals

open access: yesAnimals, 2019
Carbon dioxide (CO2) is commonly used to kill rodents. However, a large body of research has now established that CO2 is aversive to them. A multidisciplinary symposium organized by the Swiss Federal Food Safety and Veterinary Office discussed the ...
Shannon Axiak Flammer   +8 more
doaj   +1 more source

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