Results 261 to 270 of about 154,653 (347)

Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review

open access: yesThe Laryngoscope, EarlyView.
PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian   +4 more
wiley   +1 more source

Perampanel Blocks Transsynaptic α‐Synuclein Propagation and Neurodegeneration in a Mouse Model of Lewy Body Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda   +9 more
wiley   +1 more source

A Biophysical Approach to the Design of Networks of Communication Systems

open access: yesMathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT Inspired by the growth dynamics of the protist Physarum polycephalum, we employ a formalism that describes adaptive, incompressible Hagen‐Poiseuille flows on channel networks to identify graphs connecting different nodes within Euclidean space. These graphs are either suboptimal or optimal relative to their length.
Rodrigo Almeida   +2 more
wiley   +1 more source

Longitudinal Awake Mouse fMRI During Voluntary Locomotion Using Zero TE Imaging and a Novel Treadmill Training Protocol

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Functional MRI (fMRI) in awake rodents presents countless valuable opportunities for researchers to probe questions that may not be accessible through anesthetized models, such as voluntary locomotion. The commonly used echo planar imaging (EPI) sequence is highly sensitive to motion that occurs even outside of the imaging plane ...
Lauren Daley   +3 more
wiley   +1 more source

Weekly Subcutaneous VK2735, a GIP/GLP‐1 Receptor Dual Agonist, for Weight Management: Phase 2, Randomized, 13‐Week VENTURE Study

open access: yesObesity, EarlyView.
Four doses of VK2735 and a placebo group were included in the VENTURE study. Adults who were overweight or had obesity had significant weight loss when taking any dose of VK2735 for 13 weeks. More people lost at least 10% of their body weight as the dose increased.
Harold E. Bays   +9 more
wiley   +1 more source

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