Results 91 to 100 of about 9,217,738 (367)
Possibilities of Inner Ear Barrier Models for Otologic Drug Development
Advanced Therapeutics, EarlyView.This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn +7 more
wiley +1 more source
Middle ear tuberculosis: Diagnostic criteria [PDF]
, 2009 Introduction. Tuberculous otitis is a diagnostic problem due to the difficulty to obtain microbiological, histomorphological and cytological confirmation of the disease. Objective. Our objective was to compare clinical and radiological characteristic and
Dudvarski Zoran +6 more
core +1 more source
Prion, 2019 The major neurological feature of prion diseases is a neuronal loss accomplished through either apoptosis or autophagy. In this review, I compared axonal alterations in prion diseases to those described 40 years earlier as a result of nerve ligation.
P. Liberski
semanticscholar +1 more source
Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity
Advanced Science, EarlyView.This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong +16 more
wiley +1 more source
Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery
Pharmaceutics, 2021 Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication.
Rebekah Omarkhail Elliott, Mei He
doaj +1 more source
Beidseitige Ertaubung durch Labyrinthitis bei M. Crohn [PDF]
HNO, 2011 Labyrinthitis with vestibulocochlear dysfunction in chronic inflammatory bowl disease is a rare but well described manifestation or complication. The diagnostic and therapeutic possibilities and limitations of this inflammatory otopathy are presented and discussed in the context of a case report.
Weisert, J U, Veraguth, D, Probst, R
openaire +4 more sources
Derelict architecture: Aesthetics of an unaesthetic space [PDF]
, 2015 The main focus of this article is the question of the aesthetics of an unaesthetic ruined space.The author also pays particular attention to the ambivalence that exists in contemporary derelict architecture, referred to as ‘modern ruins’, and tries to ...
Nieszczerzewska, Małgorzata
core +1 more source
Advanced Science, EarlyView.Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser +11 more
wiley +1 more source
Narrative environments: how do they matter? [PDF]
, 2009 The significance and possible senses of the phrase 'narrative environment' are explored. It is argued that 'narrative environment' is not only polysemous but also paradoxical; not only representational but also performative; and not just performatively ...
Parsons, Allan
core
A 3D benign paroxysmal positional vertigo model for study of otolith disease [PDF]
, 1996 ObjectiveTo develop a three-dimensional study tool of the membranous labyrinth in order to study the pathophysiology, diagnostic workup and treatment of benign paroxysmal positional vertigo (BPPV). BPPV is the most common cause of peripheral vertigo. Its
Teixido, Michael +3 more
core +2 more sources