Results 151 to 160 of about 24,309 (324)

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

The labyrinth of bone disease in thalassaemia: the search for Ariadne’s thread continues [PDF]

, 2008
Nicos Skordis
openalex   +1 more source

Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy

Exploration, EarlyView.
BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM‐siRNA). PRM‐siRNA under near‐infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood‐brain barrier for enhanced drug delivery.
Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan   +9 more
wiley   +1 more source

Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice [PDF]

, 2017
Aagaard, Barrows, Bayer, Bin Cao, Cadwell, Cao, Cao, Cao-Lormeau, Cemma, Chibueze, Chiramel, Delorme-Axford, Delvecchio, El Costa, Elfiky, Eyer, Farias, Hamel, Indira U. Mysorekar, Jurado, Kaplan, Khan, Klionsky, Lamont, Lennemann, Levine, Liang, Lindsay A. Parnell, Martín-Acebes, Mateo, Michael S. Diamond, Miner, Mysorekar, Pirooz, Quicke, Rosenfeldt, Rossant, Sacramento, Savarino, Sharma, Shoji-Kawata, Signorelli, Tabata, Tricou, Vandergaast, Vermillion, Wenzel, Xu, Yockey, Zmurko   +49 more
core   +2 more sources

Commentary: Three questions for the study of traumatic brain injury in animals

The Anatomical Record, EarlyView.
Gregory Hollin
wiley   +1 more source

Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha

Food Frontiers, EarlyView.
Alpha‐lipoic acid (ALA) plays a significant role in alleviating isoflurane‐induced cognitive dysfunction in juvenile mice by activating PGC‐1α, which improves mitochondrial function and energy metabolism in astrocytes. As a potent antioxidant, ALA is commonly found in foods like spinach, broccoli, and yeast, and its supplementation may offer ...
Xingkai Zhao, Donglu Wang, Shuai Li, Xueting Zhang, Zhenlei Zhou   +4 more
wiley   +1 more source

Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases

Journal of Advanced Research
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases.
Jiaxing Sun, Yu Gui, Shenghua Zhou, Xi-Long Zheng   +3 more
doaj  

Forensic Psychiatric Evaluations of Juvenile Sexual Offenses and Criminal Responsibility Assessments

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescent sexual offending is a complex and multifaceted issue; however, existing research is predominantly derived from Western contexts, leading to gaps in understanding these behaviors in underrepresented regions. Criminal characteristics, psychiatric diagnoses, and cognitive factors, which are recognized to affect offending ...
Ilker Tasdemir (Taşdemir), Muhammed Emin Boylu, Mehmet Dogan (Doğan), Ahmet Safa Gurhan (Gürhan)   +3 more
wiley   +1 more source

On the role of depletive tests. a review analysis [PDF]

, 2016
An overview of the diagnostic role of depletion tests for staging Meniere’s disease, especially in the first phase of the disease, is reported.
Barbara, M, Covelli, E, Marrone, V, Monini, S, Tarentini, S   +4 more
core  

Use of Mitochondrial Delayed Luminescence Measurements From Brain Tissue to Optimize Photobiomodulation Prarameters in Alzheimer's Disease Mice

Journal of Biophotonics, EarlyView.
Photobiomodulation (808 nm laser, optimized at 80 Hz, 30% duty cycle) significantly enhances mitochondrial function, reduces β‐amyloid deposition, and attenuates microglial activation in a 5XFAD Alzheimer's mouse model. Delayed luminescence serves as a novel bioenergetic marker, linking improved mitochondrial efficiency to cognitive and ...
Hong Bae Kim, Chang Kyu Sung
wiley   +1 more source