Results 151 to 160 of about 9,217,738 (367)

Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease

, 2021
Joost Brinks, Elon H. C. van Dijk, Ingeborg Klaassen, Reinier O. Schlingemann, Szymon M. Kiełbasa, Eszter Emri, Paul H.A. Quax, Arthur A. Bergen, Onno C. Meijer, Camiel J. F. Boon   +9 more
openalex   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

DNA methylation inhibitors adverse reaction characteristic analysis: a descriptive analysis from WHO-VigiAccess

Frontiers in Pharmacology
IntroductionDNA methylation inhibitors (azacitidine, decitabine) have revolutionized the treatment dilemma of myelodysplastic syndromes (MDS), a group of malignant hematopoietic disorders.
Qiang Zhou, Quanlei Xie, Qiang Liu, Haojie Wang, Zhan Zhang, Zhao Yu, Qian Guo, Jie Lin   +7 more
doaj   +1 more source

Rare disease care pathways in the EU: from odysseys and labyrinths towards highways

, 2021
Birutė Tumienė, Holm Graeßner
openalex   +2 more sources

Visual evaluation of nystagmus intensity in points to diagnose vestibular dysfunction [PDF]

The amplitude of nystagmus multiplied by its frequency gives a value commensurate to the velocity of slow phase. If the amplitude and the frequency during the visual observation are expressed in relative units (e.g., in points ranging from 1 to 3) the ...
Levashov, M. M.
core   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

Characterization Of White Spot Syndrome Virus (WSSV) From Indonesian Shrimp Farms And Development Of Polymerase Chain Reaction (PCR) Assay For Its Detection [PDF]

, 2001
A study was carried out to clarify the viral white spot disease in Indonesian shrimp farms and to develop a polymerase chain reaction (PCR) assay for its detection.
Sunarto, Agus
core  

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Membranous labyrinth volumes in normal ears and Ménière disease: A three‐dimensional reconstruction study [PDF]

, 2009
Norimasa Morita, Shin Kariya, Armin Farajzadeh Deroee, Sebahattin Cüreoǧlu, Shigenobu Nomiya, Rie Nomiya, Tamotsu Harada, Michael M. Paparella   +7 more
openalex   +1 more source

An Effective Oral Drug Delivery Route for Pharmacokinetic Complications: Spirulina Lipid Nanotechnology System

Advanced Science, EarlyView.
Spirulina‐nano system facilitates the formation of drug coating on spirulina's surface through electrostatic adsorption. It targets intestinal villi effectively and overcomes the pharmacokinetic complications of IBS‐D. This system successfully carried out the treatment of multiple symptoms, including diarrhea, visceral hypersensitivity, mental symptoms,
Jiahui Ye, Xinyi Wu, Jin Liu, Yongmi Guo, Chong Ji, Zhouyue Wang, Di Yang, Min Zhou   +7 more
wiley   +1 more source