Results 111 to 120 of about 31,663 (206)

Specificities of three tight-binding Lac repressors

Nucleic Acids Research, 1992
Tight binding mutants of Lac repressor exhibit complex repression phenomena. In this work, in vivo Lac operator binding of three such mutants of E. coli Lac repressor (X86: ser 61-leu, l12: pro 3-tyr and the double mutant l12X86: pro 3-tyr, ser 61-leu) was analyzed.
openaire   +3 more sources

ISOLATION OF THE LAC REPRESSOR [PDF]

Proceedings of the National Academy of Sciences, 1966
W, Gilbert, B, Müller-Hill
openaire   +2 more sources

Mechanism of promoter repression by Lac repressor–DNA loops [PDF]

Nucleic Acids Res, 2013
Becker NA, Peters JP, Maher LJ, Lionberger TA.   +3 more
europepmc   +2 more sources

Price of disorder in the lac repressor hinge helix. [PDF]

Biopolymers, 2019
Seckfort D, Montgomery Pettitt B.
europepmc   +1 more source

Author Correction: Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor

Nature Communications, 2023
Anum Glasgow, Helen T. Hobbs, Zion R. Perry, Malcolm L. Wells, Susan Marqusee, Tanja Kortemme   +5 more
doaj   +1 more source

Reciprocating RNA Polymerase batters through roadblocks

Nature Communications
RNA polymerases must transit through protein roadblocks to produce full-length transcripts. Here we report real-time measurements of Escherichia coli RNA polymerase passing through different barriers. As intuitively expected, assisting forces facilitated,
Jin Qian, Allison Cartee, Wenxuan Xu, Yan Yan, Bing Wang, Irina Artsimovitch, David Dunlap, Laura Finzi   +7 more
doaj   +1 more source

The mechanism and high-free-energy transition state of lac repressor-lac operator interaction. [PDF]

Nucleic Acids Res, 2017
Sengupta R, Capp MW, Shkel IA, Record MT.   +3 more
europepmc   +1 more source

Protein directed evolution

Revista de Química, 2008
Directed evolution allows us to explore protein functionalities not required in the natural environment. It mimics natural genetic processes and selective pressures. This approach is used when the molecular basis is not completely understood and rational
Roberto Laos
doaj  

Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor. [PDF]

Chem Sci, 2020
de Geus MAR, Groenewold GJM, Maurits E, Araman C, van Kasteren SI.   +4 more
europepmc   +1 more source

Sliding of a single lac repressor protein along DNA is tuned by DNA sequence and molecular switching. [PDF]

Nucleic Acids Res, 2018
Tempestini A, Monico C, Gardini L, Vanzi F, Pavone FS, Capitanio M.   +5 more
europepmc   +1 more source