Results 61 to 70 of about 31,663 (206)

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Rhizobial motility preference in root colonization of Medicago truncatula

New Phytologist, EarlyView.
Summary Tunnel‐like infection thread (IT) structures support root colonization by symbiotic nitrogen‐fixing rhizobia bacteria in most legume species. These tip‐grown structures are key to directing rhizobia from root hairs to developing nodules, where they are hosted to fix nitrogen.
Anaïs Delers, Anne Bennion, Ambre Guillory, Lisa Frances, Elizaveta Krol, Fanny Bonnafous, Laurena Medioni, Javier Serrania, Rémi Peyraud, Joëlle Fournier, Fernanda de Carvalho‐Niebel, Anke Becker   +11 more
wiley   +1 more source

Analysis of in-vivo LacR-mediated gene repression based on the mechanics of DNA looping. [PDF]

PLoS ONE, 2006
Interactions of E. coli lac repressor (LacR) with a pair of operator sites on the same DNA molecule can lead to the formation of looped nucleoprotein complexes both in vitro and in vivo.
Yongli Zhang, Abbye E McEwen, Donald M Crothers, Stephen D Levene   +3 more
doaj   +1 more source

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

Advanced Science, Volume 13, Issue 7, 3 February 2026.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang, Chunyu Du, Guanyu Zheng, Dahu Ding   +3 more
wiley   +1 more source

Marginal Stability of the YB1 Cold‐Shock Domain in Cells Enables Binding of Multiple Nucleic Acids

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study suggests that the marginal stability of the YB1 Cold‐Shock Domain (CSDex) allows for a balance between multifunctionality and conformational changes under physiological conditions. This balance is driven by the dynamic equilibrium between the unfolded ensemble (UE) and the native ensemble (NE) of CSDex (PDB:6LMR).
Puja Shrestha, Sara S. Ribeiro, Janne Aurich, Christian Herrmann, Simon Ebbinghaus   +4 more
wiley   +1 more source

Network Topology as a Driver of Bistability in the lac Operon

, 2008
The lac operon in Escherichia coli has been studied extensively and is one of the earliest gene systems found to undergo both positive and negative control. The lac operon is known to exhibit bistability, in the sense that the operon is either induced or
Alan Veliz-Cuba, Brandilyn Stigler, Goodwin B., Griffiths A.   +3 more
core   +1 more source

DNA Sampling: a method for probing protein binding at specific loci on bacterial chromosomes [PDF]

, 2009
We describe a protocol, DNA sampling, for the rapid isolation of specific segments of DNA, together with bound proteins, from Escherichia coli K-12. The DNA to be sampled is generated as a discrete fragment within cells by the yeast I-SceI meganuclease ...
Blattner, Busby, Butala, Butala, Dame, David J. Lee, Dejardin, Gadgil, Grainger, Grainger, Griffin, Herring, Karp, Kuhar, Lee, Lodge, Matej Butala, Miller, Minchin, Mulec, Murphy, Nordhoff, Pope, Salgado, Spott, Stead, Stephen J. W. Busby, Wang, Westblade, Woo   +29 more
core   +5 more sources

Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy

MedComm, Volume 7, Issue 1, January 2026.
Obestatin signaling reactivates autophagy by NEDD4‐L activation under DMD conditions. Tyrosine switch on NEDD4‐L activates autoubiquitination that serves as a scaffold to recruit USP10 to form a deubiquitination complex, which stabilizes VPS34 to promote autophagy by activation of the Beclin1 complex. In parallel, NEDD4‐L favors AMPK exposure to CaMKKß
Icía Santos‐Zas, Silvia Costas‐Abalde, Andrea C. Lodeiro, Fátima Fernández‐Barreiro, Tania Cid‐Díaz, Saúl Leal‐López, Jessica González‐Sánchez, Mar García‐Lamela, Lucía Debasa‐Corral, Carlos S. Mosteiro, Kamel Mamchaoui, Vincent Mouly, Xesús Casabiell, Rosalía Gallego, José Luis Relova, Yolanda Pazos, Jesus P. Camiña   +16 more
wiley   +1 more source

Visualization of C. elegans transgenic arrays by GFP

BMC Genetics, 2006
Background Targeting the green fluorescent protein (GFP) via the E. coli lac repressor (LacI) to a specific DNA sequence, the lac operator (lacO), allows visualization of chromosomes in yeast and mammalian cells. In principle this method of visualization
Sternberg Paul W, Gonzalez-Serricchio Aidyl S   +1 more
doaj   +1 more source