Results 1 to 10 of about 7,921 (224)

Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome [PDF]

Annals of Child Neurology, 2020
Purpose We aimed to assess the efficacy and safety of lacosamide in Korean adolescents with Lennox-Gastaut syndrome (LGS), especially in those who concomitantly used other sodium channel blockers (SCBs).
Han Som Choi, Se Hee Kim, Hoon-Chul Kang, Joon Soo Lee, Heung Dong Kim   +4 more
doaj   +3 more sources

Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to breast milk.
Ayako Furugen, Ayako Nishimura, Takeshi Umazume, Hina Ishikawa, Katsuya Narumi, Masaki Kobayashi   +5 more
doaj   +2 more sources

Evaluation of the anti-ulcerative effects of lacosamide in a rat model of acetic acid-induced colitis [PDF]

Research in Pharmaceutical Sciences
Background and purpose: Colitis is a type of inflammatory bowel disease (IBD) with an unknown and complex etiology. Lacosamide is a known antiepileptic drug for which anti-inflammatory effects have been reported.
Mohsen Minaiyan, Niloufar Mottaghi
doaj   +2 more sources

Retrospective, Multicenter Study of Lacosamide to Treat Neonatal Seizures [PDF]

Annals of the Child Neurology Society
Objective Most antiseizure medications (ASMs) are prescribed off label for neonates. Lacosamide's efficacy in infants and availability in intravenous formulation suggest potential utility for neonates.
Alexandra Santana Almansa, Jessica R. Landers, Nicholas S. Abend, Giulia M. Benedetti, Catherine J. Chu, Andrew T. Knox, Shavonne Massey, Steffany Moen, Andrea C. Pardo, Arnold Sansevere, Renée A. Shellhaas, Cameron Thomas, Tammy Tsuchida, Sonya Wang, Bo Zhang, Janet S. Soul   +15 more
doaj   +2 more sources

The Efficacy of Lacosamide in the Treatment of Delirium Complicated With Ileus: Four Cases [PDF]

Neuropsychopharmacology Reports
Delirium is a common disease in elderly patients and requires medications, although nondrug interventions are recommended. When delirious patients are complicated with ileus, the selection of drugs would be difficult.
Shinji Sato
doaj   +2 more sources

Therapeutic drug monitoring of lacosamide as add-on treatment in a neonate with therapy-resistant epilepsy due to SCN2A mutation: a case report [PDF]

Journal of Medical Case Reports
Background Lacosamide is registered for the treatment of (partial-onset) seizures in adults and children > 2 years of age, with a recommended maximum dose of 12 mg kg-1 in two doses. It is generally well tolerated.
M. Slikkerveer, M. C. Hutten, S. Klinkenberg, A. C. S. Knijnenburg   +3 more
doaj   +2 more sources

Development and validation of a population pharmacokinetic model for lacosamide in adult patients with epilepsy to inform precision dosing [PDF]

BMC Pharmacology and Toxicology
Background Lacosamide is a third-generation antiseizure medication that reduces seizures by promoting slow inactivation of voltage-gated sodium channels. There are significant interindividual differences in the pharmacokinetics of this drug.
Lingyan Yu, Fengqian Mao, Shunan Chen, Kangzhen Yu, Yani Hu, Jie Chen, Wei Hu, Zhenwei Yu, Haibin Dai   +8 more
doaj   +2 more sources

Lacosamide versus topiramate in episodic migraine: a randomized controlled double-blinded trial [PDF]

Therapeutic Advances in Neurological Disorders
Background: Although migraine is the second most prevalent form of headache, its preventive treatment has some contraindications and complications. It has been postulated that lacosamide reacts with collapsin response mediator protein 2 and prevents its ...
Mohamed G. Zeinhom, Mohamed Fouad Elsayed Khalil, Mohamed Almoataz, Tarek Youssif Omar Youssif, Ahmed Mohamed Ali Daabis, Hossam Mohamed Refat, Ahmed Ahmed Mohamed Kamal Ebied, Shady S. Georgy, Ahmed Zaki Omar Akl, Mohamed Ismaiel, Salah Ibrahim Ahmed, Hesham Farouk Eissa, Asmaa Ibrahem Desouky Mostafa Ibrahem, Asmaa Mohammed Hassan, Mohamed Elshafei, Amir Ahmed Elsaeed Egila, Sherihan Rezk Ahmed   +16 more
doaj   +2 more sources

The real-world safety of lacosamide and perampanel in children: a disproportionality analysis of the FDA Adverse Event Reporting System [PDF]

Therapeutic Advances in Drug Safety
Background: Lacosamide and perampanel are two novel antiepileptic drugs with distinct mechanisms of action. However, the real-world evidence of adverse events (AEs) related to these drugs in children is limited. Objectives: This study aims to explore the
Yani Tan, Cuilin Li, Qin Yi, Xin Liu, Yuping Yang, Lian Zheng, Long Wei, Li Huang   +7 more
doaj   +2 more sources

The therapeutic effects of lacosamide on epilepsy-associated comorbidities

Frontiers in Neurology, 2023
Epilepsy is a chronic neurological disorder associated with severe social and psychological effects, and most epilepsy patients often report at least one comorbidity.
Zihua He, Jinmei Li
doaj   +1 more source