Results 21 to 30 of about 7,921 (224)
CNS Neuroscience & Therapeutics, 2010 SUMMARYWe will review all available studies on the use of lacosamide in the treatment of partial‐onset seizures. The available evidence includes two open‐label studies and three randomized controlled trials evaluating the safety and efficacy of oral lacosamide.
Jacklyn A, Harris, Julie A, Murphy
openaire +2 more sources
Frontiers in Pharmacology, 2021 Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow ...
Julie I. R. Labau +29 more
doaj +1 more source
Real-Life Efficacy and Tolerability of Lacosamide in Pediatric Patients Aged 4 Years or Older with Drug-Resistant Epilepsy [PDF]
Annals of Child Neurology, 2023 Purpose The aim of this study was to evaluate the efficacy and safety of adjunctive lacosamide therapy in pediatric patients aged ≥4 years with drug-resistant epilepsy (DRE).
Shin Yun Byun +6 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Lacosamide, a third-generation novel antiepileptic drug, was first approved in 2008 as an adjunct to partial seizures. In 2014, the U.S. Food and Drug Administration (FDA) approved it as a single agent for partial seizures.
Jie Chen +8 more
doaj +1 more source
Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis. [PDF]
, 2014 Alterations in voltage-gated sodium channel (VGSC) function have been linked to chronic pain and are good targets for analgesics. Lacosamide (LCM) is a novel anticonvulsant that enhances the slow inactivation state of VGSCs. This conformational state can
Wahida Rahman +3 more
core +1 more source
Lacosamide-associated second-degree atrioventricular block in a healthy, young athlete
Epilepsy & Behavior Reports, 2020 Lacosamide enhances slow inactivation of voltage-gated sodium channels and can lead to dose-dependent PR interval prolongation. Previously, lacosamide has been associated with second-degree atrioventricular (AV) heart block in the context of multiple ...
Brian Stamm +3 more
doaj +1 more source
The Effect of Lacosamide Polytherapy on Seizure Prognosis in Focal Epilepsies
, 2021 Objectives:What is expected from anti-epileptic treatment is low side effects and drug-drug interactions as well as high efficacy. In this study, the efficacy of lacosamide in polytherapy and its effect on prognosis were evaluated.Methods:Seventy-seven ...
Kezban ASLAN KARA +4 more
core +1 more source
Epilepsia Open, 2023 Objective The objective of this study is to evaluate the safety and tolerability of intravenous (IV) lacosamide infusion in patients aged ≥1 month to
Mark Kristof Farkas +7 more
doaj +1 more source
000-Lacosamide Injection CT_REPORT.pdf
, 2022 The file contains the trial data for the Lacosamide Injection study
Saurabh Pawar (13837786)
core +1 more source
Real‐world analysis of hospitalizations in patients with epilepsy and treated with perampanel
Epilepsia Open, 2021 Objectives (1) To evaluate risk of hospitalization following initiation of perampanel (pre‐ and post‐analysis) and (2) to compare hospitalization rates following initiation of perampanel vs lacosamide.
Edward Faught +4 more
doaj +1 more source