Results 121 to 130 of about 74,505 (292)

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Photoredox approach to N-Acyl-N'-aryl-N,N'-aminals using enamides and their conversion to γ-lactams [PDF]

, 2018
A photoredox catalytic approach to synthetically valuable N-acyl-N'-aryl-N,N'-aminals is described. This method uses the addition of a radical precursor to enamides, with subsequent interception of the cationic iminium intermediate with an arylamine. The
Marc Kimber (1249593), Mark Elsegood (1249893), Simon J. Teat (1304670), Olusesan K. Koleoso (6695882)   +3 more
core  

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Novel Zwitterionic Polydopamine Nanofiller‐Reinforced Hybrid Membranes With Superior Antifouling Performance for Wastewater Treatment

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work reports one‐pot synthesized novel zwitterionic polydopamine‐silica (ZSiPDA) nanofillers for fabricating PES hybrid ultrafiltration membranes with enhanced hydrophilicity, permeability, and antifouling performance. The optimized membrane achieved over 91% humic acid removal and showed strong potential for municipal wastewater treatment.
Roqaya A. Ismail, Mahendra Kumar, Tarek Lemaoui, Inas M. AlNashef, Shadi W. Hasan, Hassan A. Arafat   +5 more
wiley   +1 more source

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Practical One‐Pot Synthesis of Cyclic Conjugated Amides From Ketones

European Journal of Organic Chemistry, EarlyView.
Cyclic conjugated amides from simple ketones: a one‐pot bromoform‐mediated homologation/amidation sequence provides direct access to 20 conjugated amides, including functionalized and linear examples, in up to 91% yield. Conjugated amides are valuable building blocks in organic synthesis; however, general access to cyclic conjugated amides remains ...
Maximilian Voigtländer, Johannes F. Teichert   +1 more
wiley   +1 more source

Incidence and impact of respiratory tract infections on outcomes in patients with status epilepticus: A 20‐year longitudinal observation

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to identify the incidence of respiratory tract infections (RTIs) in a large cohort of adult patients with status epilepticus (SE) and to characterize their associations with clinical features and outcome determinants.
Sebastian Berger, Sira M. Baumann, Urs Fisch, Lisa Hert, Pascale Grzonka, Sabina Hunziker, Stephan Rüegg, Sarah Tschudin‐Sutter, Raoul Sutter   +8 more
wiley   +1 more source

One-pot synthesis of azepine spiro[4.6]-γ-lactams by a Hantzsch-type reaction

A facile route to spiro-γ-lactams containing fused seven- and five-membered rings is showcased here in a multicomponent reaction harnessing glycine. Four spiro-γ-lactams were characterised, including by X-ray diffraction techniques, showing them to be ...
Clarke, Kristen T, Gee, William J, Hopkins, Scarlet L, Clegg, Jack K   +3 more
core   +1 more source