Results 1 to 10 of about 36,210 (157)

Synergistic activity of dual β-lactams against Mycobacterium avium complex [PDF]

Microbiology Spectrum
Mycobacterium avium complex (MAC) is a nontuberculous mycobacteria that cause chronic pulmonary infections, particularly in individuals with underlying structural lung disease.
Eunjeong Shin, Khalid M. Dousa, Mary Nantongo, Sebastian G. Kurz, Steven M. Holland, Barry N. Kreiswirth, Robert A. Bonomo   +6 more
doaj   +2 more sources

Drug Discovery in the Field of β-Lactams: An Academic Perspective [PDF]

Antibiotics
β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis.
Lian M. C. Jacobs, Patrick Consol, Yu Chen   +2 more
doaj   +2 more sources

Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm

mSphere, 2022
Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradigm asserts that
Gaurav Kumar, Christos Galanis, Hunter R. Batchelder, Craig A. Townsend, Gyanu Lamichhane   +4 more
doaj   +1 more source

Hazard assessment of beta-lactams: Integrating in silico and QSTR approaches with in vivo zebrafish embryo toxicity testing

Ecotoxicology and Environmental Safety, 2022
Antibiotics have emerged as a well-known representative of pharmaceuticals and personal care products (PPCPs) by causing public health and environmental problems due to their potential toxicity.
Ying Han, Yuanyuan Ma, Bo Chen, Jingpu Zhang, Changqin Hu   +4 more
doaj   +1 more source

β-Lactams from the Ocean

Marine Drugs, 2023
The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria ...
Jed F. Fisher, Shahriar Mobashery
doaj   +1 more source

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source

Giant linear plasmids of β-lactam antibiotic producing Streptomyces [PDF]

FEMS Microbiology Letters, 1995
A survey of the total cellular DNA from five β-lactam antibiotic-producing Streptomyces spp. by pulsed field gel electrophoresis was conducted to investigate the presence of linear plasmids. Streptomyces clavuligerus NRRL 3585 contained two giant linear plasmids of 120 and 430 kb, in addition to the well-characterized 11.7 kb linear plasmid ...
Donald J. Netolitzky, Xiaoning Wu, Susan E. Jensen, Kenneth L. Roy   +3 more
openaire   +1 more source

A method to transform the β-lactam antibiotic producerStreptomyces wadayamensis [PDF]

FEMS Microbiology Letters, 1986
We have developed a transformation system for Streptomyces wadayamensis, a cephamycin C producer. 1−5 × 109 protoplasts can be obtained when late logarithmic phase cultures of this microorganisms are incubated with 10 mg/ml of lysozyme. Polyethylene glycol-Ca2+-mediated transformation of these protoplasts yielded 106 transformants per μg of pIJ702 or ...
C. Acebal, V. Rubio, G. Márquez
openaire   +1 more source

Identification of the Extracytoplasmic Function σ Factor σP Regulon in Bacillus thuringiensis

mSphere, 2022
Bacillus thuringiensis and other members of the Bacillus cereus family are resistant to many β-lactams. Resistance is dependent upon the extracytoplasmic function sigma factor σP.
Theresa D. Ho, Kelsie M. Nauta, Emma K. Luhmann, Lilliana Radoshevich, Craig D. Ellermeier   +4 more
doaj   +1 more source

Stereoselective cyanation of 4-formyl and 4-imino-?-lactams: application to the synthesis of polyfunctionalized ?-lactams [PDF]

Tetrahedron, 2012
Peer ...
Alcaide, Benito, Almendros, Pedro, Cabrero, Gema, Ruiz, M. Pilar   +3 more
openaire   +2 more sources