Results 1 to 10 of about 38,029 (118)

Chelate-conjugated β-lactams resensitize metallo-β-lactamase IMP-1-producing gram-negative bacteria against carbapenem antibiotics [PDF]

Microbiology Spectrum
Metallo-β-lactamases (MBLs) such as IMP-1 are zinc-dependent enzymes that degrade a wide range of β-lactam antibiotics, including carbapenems. Although many efforts have been made to develop MBL inhibitors, there are no approved inhibitors to date ...
Touya Toyomoto, Katsuhiko Ono, Hina Honda, Tianli Zhang, Hiroyasu Tsutsuki, Ayaka Uegama, Rika Fukushima, Keiichi Yamamoto, Yasuhito Tanaka, Kanyawee Nakburee, Worasak Kaewkong, Hitoshi Tsugawa, Tomohiro Sawa   +12 more
doaj   +2 more sources

Antimicrobial susceptibility and resistance mechanisms to antipseudomonal β-lactams in Pseudomonas aeruginosa isolates from blood [PDF]

Microbiology Spectrum
Bloodstream infection caused by Pseudomonas aeruginosa with antimicrobial resistance can be difficult to treat. Herein, we investigated antimicrobial susceptibility to major antipseudomonal β-lactams and analyzed the relationship between resistance ...
Mika Murata, Kosuke Kosai, Fujiko Mitsumoto-Kaseida, Norihito Kaku, Hiroo Hasegawa, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara   +7 more
doaj   +2 more sources

Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm

mSphere, 2022
Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradigm asserts that
Gaurav Kumar, Christos Galanis, Hunter R. Batchelder, Craig A. Townsend, Gyanu Lamichhane   +4 more
doaj   +1 more source

Hazard assessment of beta-lactams: Integrating in silico and QSTR approaches with in vivo zebrafish embryo toxicity testing

Ecotoxicology and Environmental Safety, 2022
Antibiotics have emerged as a well-known representative of pharmaceuticals and personal care products (PPCPs) by causing public health and environmental problems due to their potential toxicity.
Ying Han, Yuanyuan Ma, Bo Chen, Jingpu Zhang, Changqin Hu   +4 more
doaj   +1 more source

β-Lactams from the Ocean

Marine Drugs, 2023
The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria ...
Jed F. Fisher, Shahriar Mobashery
doaj   +1 more source

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source

Identification of the Extracytoplasmic Function σ Factor σP Regulon in Bacillus thuringiensis

mSphere, 2022
Bacillus thuringiensis and other members of the Bacillus cereus family are resistant to many β-lactams. Resistance is dependent upon the extracytoplasmic function sigma factor σP.
Theresa D. Ho, Kelsie M. Nauta, Emma K. Luhmann, Lilliana Radoshevich, Craig D. Ellermeier   +4 more
doaj   +1 more source

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

mBio, 2020
Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM ...
Tae Hwan Kim, Xun Tao, Bartolome Moya, Yuanyuan Jiao, Kari B. Basso, Jieqiang Zhou, Yinzhi Lang, Dhruvitkumar S. Sutaria, Alexandre P. Zavascki, Afonso L. Barth, Stephanie M. Reeve, Herbert P. Schweizer, Deanna Deveson Lucas, John D. Boyce, Robert A. Bonomo, Richard E. Lee, Beom Soo Shin, Arnold Louie, George L. Drusano, Jürgen B. Bulitta   +19 more
doaj   +1 more source

Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast [version 1; peer review: 2 approved]

F1000Research, 2021
Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs.
Erika Rodríguez Cavallo, Darío Méndez Cuadro, Albeiro Marrugo Padilla, Johana Marquez   +3 more
doaj   +1 more source

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Pathogens, 2021
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute and chronic infections. β-lactam antibiotics including penicillins, carbapenems, monobactams, and cephalosporins play a key role in the treatment of P.
Karl A. Glen, Iain L. Lamont
doaj   +1 more source