Results 31 to 40 of about 740,410 (298)

Historical Review of the Penicillin and Related Compounds (β – Lactams)

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2018
In spite of  the old age of beta lactam, they continue to provide good health and preventing human diseases by virtue of  industrial production and discoveries of small new beta-lactam group of secondary metabolite.
Luma Salman Abd
doaj   +1 more source

Involvement of O8-antigen in altering β-lactam antibiotic susceptibilities inEscherichia coli [PDF]

FEMS Microbiology Letters, 2008
In spite of being dispensable, O-antigens are believed to facilitate various cellular processes and alter antibiotic sensitivities. Escherichia coli K-12 (CS109) strains are lacking in O-antigens and are reported to be sensitive to antibiotics. To our surprise, E. coli 2443 (expressing O8-antigen) manifested two- to fourfold higher sensitivities toward
Sujoy K, Sarkar, Anindya S, Ghosh
openaire   +2 more sources

In vitro and in vivo activity of d-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Acta Pharmaceutica Sinica B, 2019
As d-amino acids play important roles in the physiological metabolism of bacteria, combination of d-amino acids with antibiotics may provide synergistic antibacterial activity.
Qing Wang, Yuemeng Lv, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li, Xuefu You   +12 more
doaj   +1 more source

Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing β-lactam resistance [PDF]

FEMS Microbiology Letters, 2004
To understand the regulation of the MexAB OprM efflux system in a clinical strain of Pseudomonas aeruginosa presenting a decreased susceptibility to ticarcillin and aztreonam, the mexR repressor gene was amplified by polymerase chain reaction (PCR) and was shown to be disrupted by an insertion sequence of more than 2 kb, with characteristic direct and ...
Boutoille, David, Corvec, Stéphane, Caroff, Nathalie, Giraudeau, Cécile, Espaze, Eric, Caillon, Jocelyne, Plesiat, Patrick, Reynaud, Alain   +7 more
openaire   +2 more sources

Molecular epidemiology of Klebsiella pneumoniae resistant to beta-lactams antibiotics isolated from health centers of Aragua State-Venezuela

Kasmera, 2020
K. pneumoniae resistance to β-lactam antibiotics is a public health problem. The objective was to characterize by molecular epidemiology isolates of K.
Lisbeth Carolina Sierra, Ysvette Vasquez, Luis Perez-Ybarra, María Victoria Mendez López   +3 more
doaj   +1 more source

Inducible Resistance to β-Lactams in Oxacillin-Susceptible mecA1-Positive Staphylococcus sciuri Isolated From Retail Pork

Frontiers in Microbiology, 2021
Most isolated strains of Staphylococcus sciuri contain mecA1, the evolutionary origin of mecA, but are sensitive to β-lactams (OS-MRSS, oxacillin-susceptible mecA1-positive S. sciuri).
Yifei Cai, Liangjun Zheng, Yao Lu, Xu Zhao, Yanting Sun, Xingyuan Tang, Jinhe Xiao, Chen Wang, Chao Tong, Lili Zhao, Yingping Xiao, Xin Zhao, Huping Xue   +12 more
doaj   +1 more source

Thefiblocus inStreptococcus pneumoniaeis required for peptidoglycan crosslinking and PBP-mediated β-lactam resistance [PDF]

FEMS Microbiology Letters, 2000
Penicillin resistance in pneumococci is mediated by modified penicillin-binding proteins (PBPs) that have decreased affinity to beta-lactams. In high-level penicillin-resistant transformants of the laboratory strain Streptococcus pneumoniae R6 containing various combinations of low-affinity PBPs, disruption of the fib locus results in a collapse of PBP-
B, Weber, K, Ehlert, A, Diehl, P, Reichmann, H, Labischinski, R, Hakenbeck   +5 more
openaire   +2 more sources

An update on the synthesis and reactivity of spiro-fused β-lactams

Arkivoc, 2019
Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic methodologies and pharmacological applications.
Dao Thi, Hang, D'hooghe, Matthias
openaire   +2 more sources

Restoration of effectiveness of β-lactams on methicillin-resistantStaphylococcus aureusby tellimagrandin I from rose red [PDF]

FEMS Microbiology Letters, 2000
We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of beta-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of beta-lactams from the extract, tellimagrandin I and rugosin B.
S, Shiota, M, Shimizu, T, Mizusima, H, Ito, T, Hatano, T, Yoshida, T, Tsuchiya   +6 more
openaire   +2 more sources

Synthesis of Some New Mono- and Bis-Polycyclic Aromatic Spiro and Bis-Nonspiro-β-Lactams

Molecules, 2010
Some new mono-and bis-polycyclic aromatic spiro-β-lactams and bis-non spiro-polycyclic aromatic β-lactams have been synthesized from imines derived from anthracene-9-carbaldehyde, 2-naphtaldehyde and a ketene derived from 9H-xanthene-9-carboxylic acid ...
Edris Ebrahimi, Aliasghar Jarrahpour
doaj   +1 more source