Results 11 to 20 of about 38,167 (247)

Giant linear plasmids of β-lactam antibiotic producing Streptomyces [PDF]

FEMS Microbiology Letters, 1995
A survey of the total cellular DNA from five β-lactam antibiotic-producing Streptomyces spp. by pulsed field gel electrophoresis was conducted to investigate the presence of linear plasmids. Streptomyces clavuligerus NRRL 3585 contained two giant linear plasmids of 120 and 430 kb, in addition to the well-characterized 11.7 kb linear plasmid ...
Donald J. Netolitzky, Xiaoning Wu, Susan E. Jensen, Kenneth L. Roy   +3 more
openaire   +1 more source

A method to transform the β-lactam antibiotic producerStreptomyces wadayamensis [PDF]

FEMS Microbiology Letters, 1986
We have developed a transformation system for Streptomyces wadayamensis, a cephamycin C producer. 1−5 × 109 protoplasts can be obtained when late logarithmic phase cultures of this microorganisms are incubated with 10 mg/ml of lysozyme. Polyethylene glycol-Ca2+-mediated transformation of these protoplasts yielded 106 transformants per μg of pIJ702 or ...
C. Acebal, V. Rubio, G. Márquez
openaire   +1 more source

Stereoselective cyanation of 4-formyl and 4-imino-?-lactams: application to the synthesis of polyfunctionalized ?-lactams [PDF]

Tetrahedron, 2012
Peer ...
Alcaide, Benito, Almendros, Pedro, Cabrero, Gema, Ruiz, M. Pilar   +3 more
openaire   +2 more sources

Spherical and rod shaped protoplasts from β-lactam antibiotic treated cultures of Bacillus subtilis [PDF]

FEMS Microbiology Letters, 1988
Addition of β-lactams to exponentially growing cultures of an autolytically deficient Bacillus subtilis metc3 lyt-2 strain FJ6 caused increase in optical density to stop after 1 h when it had about doubled, and thereafter to remain constant for at least 6 h.
G. Wright, H.J. Rogers
openaire   +1 more source

NMR spectrometric assay for determining enzymatic hydrolysis of β-lactam antibiotics with bacteria in aqueous solution [PDF]

FEMS Microbiology Letters, 1984
An application of a nuclear magnetic resonance (NMR) spectrometer for the measurement of β-lactamase activity in clinical material containing bacteria is presented. By means of proton (1H)-NMR, it was easy to measure quantitatively β-lactamase activity in human bacteriuria, without performing any such pretreatment as isolation of bacteria or extraction
Koji O'hara, Yoko Shiomi, Megumi Kono
openaire   +1 more source

Initiation of murein biosynthesis inEscherichia colicells treated with β-lactam antibiotics [PDF]

FEMS Microbiology Letters, 1987
The study of the synthesis and accumulation of murein in cells initiating growth in the presence of β-lactam antibiotics indicated: (i) Murein rearrangement contributes substantially to cell enlargement during the first doubling in cell mass; (ii) Penicillin-binding protein 2 has the potential capability to synthesize most, if not all, the new murein ...
Antonio G. Pisabarro, Francisco Garcia Portillo, Enrique J. Rosa, Miguel A. Pedro   +3 more
openaire   +1 more source

Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams

Molecules, 2010
Because of their interesting biological properties various methods for the synthesis of substituted pyrroles are described in the literature. However, synthesis of pyrroles fused with a β-lactam ring has not been reported.
Bimal K. Banik, Hector Aguilar, Isabel Salinas, Gildardo Rivera, Debasish Bandyopadhyay   +4 more
doaj   +1 more source

Bacterial temporal dynamics enable optimal design of antibiotic treatment. [PDF]

PLoS Computational Biology, 2015
There is a critical need to better use existing antibiotics due to the urgent threat of antibiotic resistant bacteria coupled with the reduced effort in developing new antibiotics.
Hannah R Meredith, Allison J Lopatkin, Deverick J Anderson, Lingchong You   +3 more
doaj   +1 more source

Report of β-lactam antibiotic–induced vancomycin-resistant Staphylococcus aureus from a university hospital in Egypt

New Microbes and New Infections, 2019
We report a case of hospital-acquired pneumonia that to our knowledge is the first description in Egypt of the emergence of vancomycin (VA)-resistant Staphylococcus aureus due to the concomitant use of β-lactams.
A.E. Taha, M.F. Badr, F.E. El-Morsy, E. Hammad   +3 more
doaj   +1 more source

Multi-Dimensional Elimination of β-Lactams in the Rural Wetland: Molecule Design and Screening for More Antibacterial and Degradable Substitutes

Molecules, 2022
Restricted economic conditions and limited sewage treatment facilities in rural areas lead to the discharge of small-scale breeding wastewater containing higher values of residual beta-lactam antibiotics (β-lactams), which seriously threatens the aquatic
Shuhai Sun, Zhuang Li, Zhixing Ren, Yu Li   +3 more
doaj   +1 more source