Results 41 to 50 of about 740,410 (298)

Characterization of the membrane sensor PenJ for β-lactam antibodies fromBacillus licheniformisby amino acid substitution [PDF]

FEMS Microbiology Letters, 1993
The PenJ protein of the penicillinase gene (penP) expression system from Bacillus licheniformis is an antirepressor and membrane receptor for beta-lactam antibiotics. A putative beta-lactam antibiotic binding site including Ser402 and Lys405, which are homologous to the conserved sequence for the beta-lactam binding site (Ser-X-X-Lys) is present.
M, Takagi, T, Ohta, S, Johki, T, Imanaka
openaire   +2 more sources

Clinical effectiveness of beta-lactams versus fluoroquinolones as empirical therapy in patients with diabetes mellitus hospitalized for urinary tract infections: A retrospective cohort study.

PLoS ONE, 2022
BackgroundDiabetic patients are at risk of severe urinary tract infections (UTIs). Due to the emerging resistance rates to fluoroquinolones and β-lactams, we aimed to evaluate the effectiveness of β-lactams versus fluoroquinolones as empirical therapy ...
Yu-Hsin Tang, Po-Liang Lu, Ho-Yin Huang, Ying-Chi Lin   +3 more
doaj   +1 more source

Decreased membrane permeability in a polymyxin B-resistantEscherichia colimutant exhibiting multiple resistance to β-lactams as well as aminoglycosides [PDF]

FEMS Microbiology Letters, 1998
A laboratory mutant of Escherichia coli stably resistant to more than 36,000 U ml-1 of polymyxin B was isolated. The mutant exhibited moderate increases in minimum inhibitory concentration to fluoroquinolones and bacitracin but high levels of cross-resistance to beta-lactams and aminoglycosides.
S O, Rahaman, J, Mukherjee, A, Chakrabarti, S, Pal   +3 more
openaire   +2 more sources

High serum β-lactams specific/total IgE ratio is associated with immediate reactions to β-lactams antibiotics. [PDF]

PLoS ONE, 2015
Total serum IgE result from the combination of specific and non-specific pools. High specific/total IgE ratio may reflect high level of allergen-specific IgE on mast cells. No data regarding its applications to drug allergies is available.
Alessandra Vultaggio, Gianni Virgili, Francesco Gaeta, Antonino Romano, Enrico Maggi, Andrea Matucci   +5 more
doaj   +1 more source

Gold-catalyzed bis-cyclization of 1,2-diol- or acetonide-tethered alkynes. Synthesis of ?-lactam-bridged acetals: a combined experimental and theoretical study [PDF]

Tetrahedron, 2012
Peer ...
Alcaide, Benito, Almendros, Pedro, Carrascosa, Rocío, López, Ramón, Menéndez, María I.   +4 more
openaire   +2 more sources

Isothiourea-catalyzed asymmetric synthesis of β-lactams and β-amino esters from arylacetic acid derivatives and N-sulfonylaldimines

, 2014
This work is supported by a Royal Society for a University Research Fellowship and the EPSRC and GSK (Case Award) as well as by the European Research Council under the European Unionʼs Seventh Framework Programme (FP7/2007-2013) (ERC Grant Agreement No ...
Prevet, Hugues, Shapland, Peter, Smith, Andrew D., Douglas, James, Smith, Siobhan R., Slawin, Alexandra M. Z.   +5 more
core   +1 more source

The barrier function of the outer membrane ofPseudomonas maltophiliain the diffusion of saccharides and β-lactam antibiotics [PDF]

FEMS Microbiology Letters, 1989
This paper reports that the efficiency of solute diffusion through the outer membrane of Pseudomonas maltophilia is roughly 3 to 5% of that of Escherichia coli. This is despite the fact that the outer membrane pore(s) is only a little smaller than that of E. coli. These results suggest that P. maltophilia has a low copy number of porin(s).
E, Yamazaki, J, Ishii, K, Sato, T, Nakae
openaire   +2 more sources

β-Lactam induction of ISEcp1B-mediated mobilization of the naturally occurringbla_CTX-Mβ-lactamase gene ofKluyvera ascorbata [PDF]

FEMS Microbiology Letters, 2008
ISEcp1B is an insertion element associated with the emerging expanded-spectrum beta-lactamase bla(CTX-M) genes in Enterobacteriaceae. Because ISEcp1B-bla(CTX-M)positive strains may be identified from humans and animals, the ability of this insertion sequence to mobilize the bla(CTX-M-2) gene was tested from its progenitor Kluyvera ascorbata to study ...
Nordmann, Patrice, Lartigue, Marie-Frédérique, Poirel, Laurent   +2 more
openaire   +3 more sources

Facile synthesis of novel benzothiazolylpyrazolyl anchored 3-thio/seleno/chloro-β-lactams: Synthetic intermediates for novel 3-sulfenyl/sulfonyl, C-3 functionalized monocyclic and spirocyclic β-lactams

, 2018
Efficient synthesis of a new series of 3-phenyl/benzylthio-4-benzothiazolylpyrazolyl-β-lactams is described. Treatment of 2-phenylthio/benzylthioacetic acid with benzothiazolylpyrazolyl substituted Schiff’s bases furnished trans-β-lactams exclusively ...
Jitender Bhalla (4284292), Aman Bhalla (3832465), Shamsher S. Bari (3832459)   +2 more
core   +1 more source

β-Lactamase-non-producing ampicillin-resistant Haemophilus influenzae is acquiring multidrug resistance

Journal of Infection and Public Health, 2020
Background: Haemophilus influenzae strains with reduced susceptibilities to antimicrobial agents have emerged in Japan. Here, we aimed to investigate H. influenzae non-susceptibility to β-lactams and non-β-lactams. Methods: A total of 260 H.
Shogo Yamada, Shoji Seyama, Takeaki Wajima, Yuna Yuzawa, Masumi Saito, Emi Tanaka, Norihisa Noguchi   +6 more
doaj   +1 more source