Results 61 to 70 of about 740,410 (298)
Bifunctional Asymmetric Catalysis: A Tandem Nucleophile/Lewis Acid Promoted Synthesis of β-Lactams
, 2016 We describe a superior procedure for the catalytic, asymmetric synthesis of β-lactams using a bifunctional catalyst system consisting of a chiral nucleophile and an achiral Lewis ...
Ahmed M. Hafez (2714233) +5 more
core +1 more source
Advanced Science, EarlyView.Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang +11 more
wiley +1 more source
Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries
Angewandte Chemie, EarlyView.This review explores how bidentate directing auxiliaries have advanced transition‐metal catalysis for unactivated alkene/alkyne functionalization. By leveraging chelated intermediates, bidentate directing auxiliaries enable precise hydrofunctionalization, difunctionalization, and C─H activation of π‐bonds with unique selectivity and reactivity.
Seunghyeon Cho +4 more
wiley +2 more sources
eLife, 2017 Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams.
Saurabh Mishra +10 more
doaj +1 more source
Antibiotics, 2021 Septic shock substantially alters the pharmacokinetic properties of β-lactams with a subsequently high risk of insufficiently low serum concentrations and treatment failure.
Daniel Christoph Richter +12 more
doaj +1 more source
Replacement of the essential penicillin-binding protein 5 by high-molecular mass PBPs may explain vancomycin-β-lactam synergy in low-level vancomycin-resistant Enterococcus faecium D366 [PDF]
FEMS Microbiology Letters, 1992 The mechanism of synergy between vancomycin and penicillin, as well as other beta-lactam antibiotics, was examined in a penicillin-resistant E. faecium (D366) expressing an inducible low-level resistance to vancomycin. It was demonstrated that penicillin per se was not able to reduce the inducible expression of the 39.5-kDa protein (VANB) or the ...
S, al-Obeid +4 more
openaire +2 more sources
Advanced Science, EarlyView.High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott +5 more
wiley +1 more source
Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
Angewandte Chemie, EarlyView.A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter +5 more
wiley +2 more sources
Mycobacterium abscessus and β-Lactams: Emerging Insights and Potential Opportunities
Frontiers in Microbiology, 2018 β-lactams, the most widely used class of antibiotics, are well-tolerated, and their molecular mechanisms of action against many bacteria are well-documented.
Elizabeth Story-Roller +3 more
doaj +1 more source
Advanced Science, 2021 Implant infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) can cause major complications during the perioperative period. Diclofenac, one of the most widely used nonsteroidal anti‐inflammatory drugs, is often used to relieve pain and
Shutao Zhang +6 more
doaj +1 more source