Results 81 to 90 of about 740,410 (298)

Molecular bases determining daptomycin resistance-mediated re-sensitization to β-lactams ("see-saw effect") in MRSA [PDF]

, 2017
Antimicrobial resistance is recognized as one of the principal threats to public health worldwide, yet the problem is increasing. Methicillin-resistant Staphylococcus aureus (MRSA) are among the most difficult to treat in clinical settings due to the ...
Margolin, William, Turner, R.D., Rosato, R.R., Roch, M., Renzoni, A.M., Martinez, M.P., Foster, S.J., Turner, Robert D., Haeusser, D.P., Roch, Melanie, Martinez, Maria P. [0000-0003-3927-8846], Fatouraei, Maryam, Rosato, Adriana E., Kelley, William L., Kelley, William, Haeusser, Daniel P., Renzoni, Adriana Maria, Margolin, W., Fenn, S., Kelley, W.L., Renzoni, Adriana, Foster, Simon J., Rosato, Roberto R., Fenn, Samuel, Martinez, Maria P., Fatouraei, M., Rosato, A.E.   +26 more
core   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Rapid and Highly Diastereoselective Synthesis of α-Bromo N-Alkoxy β-Lactams from α,β-Unsaturated Silyl Imino Ethers

, 2023
The preparation of the β-lactam motif containing both C-Br and N-O bonds as functional handles remains an unmet synthetic challenge. Described herein is a novel diastereoselective NBS-mediated cyclization of N-alkoxy α,β-unsaturated silyl imino ethers to
Daniel, Ess, Justin, Kirkland, Laszlo, Kurti, Pierre, Loch-Temzelides, Muhammed, Yousufuddin, Michael, Davenport, Agustin, Rodriguez Trevino, Sanjay, Pandiri, Ulises, Aguinaga   +8 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

In vitro activity of ceftolozane–tazobactam and ceftazidime–avibactam against clinical isolates of meropenem-non-susceptible Pseudomonas aeruginosa: A two-centre study

Journal of Global Antimicrobial Resistance, 2020
Objectives: This study aimed to compare the activity of ceftazidime–avibactam (C/A), ceftolozane–tazobactam (C/T) and three anti-pseudomonal β-lactams (piperacillin–tazobactam, ceftazidime and cefepime) against a collection of meropenem-non-susceptible ...
Hasan Cenk Mirza, Elvan Hortaç, Aylin Altay Koçak, M. Hamiyet Demirkaya, Buket Yayla, Aylin Üsküdar Güçlü, Ahmet Başustaoğlu   +6 more
doaj   +1 more source

Synthesis of Novel Chiral Spiroisoxazolidine‐β‐Lactams from 6‐Alkylidenepenicillanates: A 1,3‐Dipolar Cycloaddition Approach

, 2020
The synthesis of a library of 6‐alkylidene‐β‐lactams, derived from 6‐aminopenicillanic acid is reported. The 1,3‐dipolar cycloaddition of these 6‐alkylidenepenicillanates with nitrones was explored as an approach to synthesize novel chiral ...
Teresa M. V. D. Pinho e Melo, Melo, Teresa M. V. D. Pinho e, Américo J. S. Alves, Alves, Américo J. S.   +3 more
core   +1 more source

Guidelines for Detecting the Foodborne Antibiotic‐Resistant Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Foodborne antibiotic‐resistant bacteria threaten global public health and the economic. Standardized detection methods are crucial for effective prevention and control. Researchers encounter difficulties in choosing suitable techniques due to the variety of available approaches and the intricate nature of resistance mechanisms.
Yuanye Zeng, Fengxia Yang
wiley   +1 more source

β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview

Infectious Diseases and Therapy, 2023
Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives.
Dhiviya Prabaa Muthuirulandi Sethuvel, Yamuna Devi Bakthavatchalam, Maruthan Karthik, Madhumathi Irulappan, Rahul Shrivastava, Hariharan Periasamy, Balaji Veeraraghavan   +6 more
doaj   +1 more source

Photoinduced Temperature-Regulated Selective Carbene C–H Insertion for the Synthesis of Functionalized Spiro-β-lactones and -lactams

, 2023
A temperature-regulated catalyst-free photoinduced selective carbene C–H insertion strategy was realized to efficiently synthesize spiro-β-lactones and -lactams, which hold considerable promise in drug discovery programs.
Durga Prasad Hari, Bhismalochan Ghorai, Abdur Rouf Samim Mondal, Bhismalochan Ghorai (16269898), Durga Prasad Hari (1344915), Abdur Rouf Samim Mondal (16269895)   +5 more
core   +1 more source