Results 71 to 80 of about 740,410 (298)

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Copper-Catalyzed Enantioconvergent Radical C(sp³)–N Cross-Coupling to Access Chiral α‑Amino-β-lactams

A copper-catalyzed enantioconvergent radical C­(sp3)–N cross-coupling of racemic tertiary α-bromo-β-lactams with aromatic amines is developed under mild thermal reaction conditions.
Wei-Long Liu (2413084), Xin-Yuan Liu (165228), Jing-Jing Zheng (3777487), Ji-Jun Chen (809878), Qiang-Shuai Gu (6162173), Zhong-Liang Li (2953734)   +5 more
core   +2 more sources

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Enantioselective Total Syntheses of [6R,7R] and [6S,7S] Tricyclic β-Lactams

, 2016
The reaction of Ox-glycyl chloride with a chiral imine derived from the combination of d-(R)-glyceraldehyde acetonide and protected d-threonine afforded optically active, highly functionalized cis-substituted β-lactams 11 and 12.
Chuansheng Niu (3036279), Teresia Pettersson (3036276), Marvin J. Miller (398964)   +2 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Cobalt-Catalyzed One-Pot Three-Component Coupling Route to β-Acetamido Carbonyl Compounds:  A General Synthetic Protocol for γ-Lactams

, 2016
An efficient improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol.
Javed Iqbal (2121922), I. Nageshwar Rao (3032109), Saibal Kumar Das (3032112), E. N. Prabhakaran (3031473)   +3 more
core   +1 more source

Insights into the anticancer activity of chiral alkylidene-β-lactams and alkylidene-γ-lactams: Synthesis and biological investigation

, 2022
Chiral alkylidene-β-lactams and alkylidene-γ-lactams were synthesized and screened for their in vitro activity against four human cancer cell lines (melanoma, esophageal, lung and fibrosarcoma carcinoma).
Ribeiro, Ana Bela Sarmento, Laranjo, Mafalda, Gonçalves, Ana Cristina, Botelho, M. Filomena, Alves, Nuno G., Alves, Américo J. S., Gomes, Clara S. B., Pinho e Melo, Teresa M. V. D.   +7 more
core   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Structural comparison of substrate-binding pockets of serine β-lactamases in classes A, C, and D

Journal of Enzyme Inhibition and Medicinal Chemistry
β-lactams have been the most successful antibiotics, but the rise of multi-drug resistant (MDR) bacteria threatens their effectiveness. Serine β-lactamases (SBLs), among the most common causes of resistance, are classified as A, C, and D, with numerous ...
Hyeonmin Lee, Hyunjae Park, Kiwoong Kwak, Chae-eun Lee, Jiwon Yun, Donghyun Lee, Jung Hun Lee, Sang Hee Lee, Lin-Woo Kang   +8 more
doaj   +1 more source

Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics

, 2002
Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity ...
Ronald H.B. Galt, Michael I. Page, Hadfield, Peter S., Page, Michael I., Peter S. Hadfield, Bartholomew Vilanova, Lorraine A. Casey, Galt, Ronald H.B., Casey, Lorraine A., Vilanova, Bartholomew, Galt, Ronald H. B.   +10 more
core   +1 more source