Results 101 to 110 of about 68,227 (310)

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

Regio- and Stereocontrolled Metal-Mediated Carbonyl Propargylation or Allenylation of Enantiomerically Pure Azetidine-2,3-diones:  Synthesis of Highly Functionalized 3-Substituted 3-Hydroxy-β-lactams

, 2016
Regio- and stereocontrolled metal-mediated Barbier-type reactions of azetidine-2,3-diones with differently substituted propargyl bromides offer an efficient asymmetric entry to densely functionalized 3-propargyl- (or allenyl-) substituted 3-hydroxy-β ...
Benito Alcaide (1554658), Cristina Aragoncillo (1771678), Pedro Almendros (1554667)   +2 more
core   +1 more source

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams [PDF]

, 2018
Glycosylation significantly alters the biological and physicochemical properties of small molecules. beta-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In
Piens, Nicola, Dewitte, Griet, Decuyper, Lena, Shari Dhaene (5953292), Matthias D’hooghe, Kevin Vandoorne, Lena Decuyper, Maarten Debruyne, Desmet, Tom, Kevin Vandoorne (5953298), Debruyne, Maarten, Lena Decuyper (5953286), Maarten Debruyne (5953295), Shari Dhaene, Tom Desmet (1474720), Nicola Piens, Tom Desmet, Griet Dewitte (1474732), Franceus, Jorick, Jorick Franceus, D'hooghe, Matthias, Jorick Franceus (5953289), Matthias D’hooghe (1789012), Nicola Piens (5953301), Dhaene, Shari, Vandoorne, Kevin, Griet Dewitte   +26 more
core   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Photoredox-Catalyzed Tandem Radical Cyclization/Hydroxylation for the Synthesis of 4‑Hydroxyalkyl-3,3-difluoro-γ-lactams

The photoredox-catalyzed radical difluoroalkylation/cyclization/hydroxylation cascade reaction of various 2-bromo-2,2-difluoro-N-arylacetamides containing unactivated alkene moieties has been developed, providing green and efficient access to various 4 ...
Can Jin (685561), Bin Sun (210373), Jieli Yin (12493425), Haiyun Zhao (3569897), Kesheng Zhang (13882708), Xiaohui Zhuang (827046)   +5 more
core   +1 more source

Ni-Catalyzed Enantioselective CAcylation of Substituted Lactams [PDF]

, 2016
A new strategy for catalytic enantioselective C-acylation to generate α-quaternary-substituted lactams is reported. Ni-catalyzed three-component coupling of lactam enolates, benzonitriles, and aryl halides produces β-imino lactams that then afford β-keto
Eichman, Chad C., Satoshi Hashimoto, Masaki Hayashi, Chad C. Eichman, Shoshana Bachman, Hashimoto, Satoshi, Bachman, Shoshana, Brian M. Stoltz, Stoltz, Brian M., Hayashi, Masaki   +9 more
core   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Mycobacterium abscessus and β-Lactams: Emerging Insights and Potential Opportunities

Frontiers in Microbiology, 2018
β-lactams, the most widely used class of antibiotics, are well-tolerated, and their molecular mechanisms of action against many bacteria are well-documented.
Elizabeth Story-Roller, Emily C. Maggioncalda, Keira A. Cohen, Gyanu Lamichhane   +3 more
doaj   +1 more source

The enzymes of β-lactam biosynthesis

Nat. Prod. Rep., 2013
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam ...
Hamed, R, Gomez-Castellanos, JR, Henry, L, Ducho, C, McDonough, M, Schofield, C   +5 more
openaire   +3 more sources