Results 111 to 120 of about 74,505 (292)

From In Vitro Cytotoxicity to In Vivo Zebrafish Assays: A Study on 3,3-Dichloro β-, γ- and δ-Lactams and Their Biological Activity Profiles

Pharmaceuticals
Background/Objectives: Anticancer research is a constantly evolving field due to cancer’s complexity and adaptability. This study aims to evaluate the hemolytic behavior and cytotoxic properties of ten 3,3-dichlorolactams against A431 tumor and 3T3 ...
Faïza Diaba, María del Carmen Morán, Elisabet Teixidó   +2 more
doaj   +1 more source

Cefepime exposure in prolonged or intermittent infusion in critically ill children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient.
Marc Hobeika, Deborah Hirt, Emmanuelle Bille, Sihem Benaboud, Julie Toubiana, Pierre‐Louis Léger, Jérôme Rambaud, Agathe Béranger, Delphine Callot, Sylvain Renolleau, Jean‐Marc Treluyer, Mehdi Oualha, Noémie de Cacqueray   +12 more
wiley   +1 more source

Deciphering unexploited features of drug-repurposing beta-lactams against tuberculosis : from genomic patterns of Mycobacterium tuberculosis susceptibility to synergistic combinations

, 2023
Tuberculosis (TB) still figures as one of the leading death causes by a single infectious agent worldwide. The natural capacity of Mycobacterium tuberculosis (Mtb) to evade and subvert host immune responses, coupled with the increasing threat of drug ...
Olivença, Francisco
core  

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

The Mechanism of Visible‐Light Photochemical Rearrangements of Conjugated Amide Enolates

Chemistry – A European Journal, EarlyView.
Visible light irradiation of extended enolates of N‐benzylamides leads to homolytic C─N Bond cleavage, generating a biradical. Computational and mechanistic studies suggest rapid radical recombination within a solvent cage to give either ring‐expanded or rearranged products. ABSTRACT Deprotonation of conjugated amides forms colored solutions of lithium
James Mortimer, William Terry‐Wright, Basile F. E. Curchod, Jonathan Clayden   +3 more
wiley   +1 more source

ATTEMPTED SYNTHESIS OF QUINONEMETHINE DERIVATIVE OF NOCARDICIN A ANALOGUES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
The synthesis of some 13-lactams is described. 'The electronic activation of monocyclic B-lactams provided by a quinonemethine function was found to instabilize the 13-lactam ring toward nucleophilic: attack by ...
doaj  

Structural comparison of substrate-binding pockets of serine β-lactamases in classes A, C, and D

Journal of Enzyme Inhibition and Medicinal Chemistry
β-lactams have been the most successful antibiotics, but the rise of multi-drug resistant (MDR) bacteria threatens their effectiveness. Serine β-lactamases (SBLs), among the most common causes of resistance, are classified as A, C, and D, with numerous ...
Hyeonmin Lee, Hyunjae Park, Kiwoong Kwak, Chae-eun Lee, Jiwon Yun, Donghyun Lee, Jung Hun Lee, Sang Hee Lee, Lin-Woo Kang   +8 more
doaj   +1 more source

Synthesis of Tris(indol‐3‐yl)methanes From Indoles, CO2, and Dimethylphenylsilane With BPh3: Two‐Step Construction of π‐Conjugated Systems

Chemistry – A European Journal, EarlyView.
Tris(indol‐3‐yl)methanes were synthesized from indoles, CO2, and PhMe2SiH in the presence of BPh3 in acetonitrile at 50°C. One product, tris(4‐bromo‐1‐methylindol‐3‐yl)methane, underwent a palladium‐catalyzed cascade reaction for the formation of a novel polycyclic heteroaromatic compound, where the methine C(sp3) atom originating from CO2 was ...
Sha Li, So Saibara, Reito Yasui, Kazuto Takaishi, Natsumi Nitta, Tadashi Ema   +5 more
wiley   +1 more source

N‐Sulfonyl Azalevoglucosan: A Versatile Platform for the Synthesis of Polysubstituted Piperidines

Chemistry – A European Journal, EarlyView.
Gain by strain: The synthesis of a levoglucosan analog, in which the pyranose oxygen has been replaced by a nitrogen, allows navigation on the piperidine ring to iteratively install functional groups at C1, C2, C3, C4, and C6 positions using simple experimental protocols with minimal protecting group manipulation.
Dylan Yorga, Jérôme Marrot, Ana Poveda, Nicolas Auberger, Jesús Jiménez‐Barbero, Jérôme Désiré, Yves Blériot   +6 more
wiley   +1 more source

Designing a Triplet 2‐Formylphenylnitrene With Fast Tunneling Reactivity

Chemistry – A European Journal, EarlyView.
A 3‐CF3 substituent accelerates tunneling in triplet 2‐formylphenylnitrene, making its reactivity in cryogenic matrices too fast for conventional IR spectroscopic detection. Bringing this chemistry to low‐temperature solutions allows suppression of intrinsic nitrene dimerization through faster cyclization, which even outcompetes the 1,4‐H shift ...
Sofia Braz, Cláudio M. Nunes, Simon Schlosser, Peter R. Schreiner, Rui Fausto   +4 more
wiley   +1 more source