Results 111 to 120 of about 68,227 (310)

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Nickel-Catalyzed Aminofluoroalkylative Cyclization of Styrenes with Ethyl Fluoroacetate and Anilines toward Fluoro-γ-Lactams

A novel method for the nickel-catalyzed multicomponent aminofluoroalkylation/cyclization of styrenes with ethyl fluoroacetate and anilines has been developed. This protocol provides general and efficient access to a diverse range of fluoro-γ-lactams from
Xiao-Feng Wu (1617313), Fengxiang Zhu (2890865), Ziyan Li (3590381)   +2 more
core   +1 more source

Metal-Promoted Allylation, Propargylation, or Allenylation of Azetidine-2,3-diones in Aqueous and Anhydrous Media. Application to the Asymmetric Synthesis of Densely Functionalized 3-Substituted 3-Hydroxy-β-lactams

, 2016
Metal-mediated carbonyl allylation, allenylation, and propargylation of optically pure azetidine-2,3-diones were investigated in both anhydrous and aqueous environments.
Benito Alcaide (1554658), Cristina Aragoncillo (1771678), Pedro Almendros (1554667), Raquel Rodríguez-Acebes (2647213)   +3 more
core   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Excited-State Copper-Catalyzed [4 + 1] Annulation Reaction Enables Modular Synthesis of α,β-Unsaturated-γ-Lactams

Synthesis of α,β-unsaturated-γ-lactams continue to attract attention due to the importance of this structural motif in organic chemistry. Herein, we report the development of a visible-light-induced excited-state copper-catalyzed [4 + 1] annulation ...
Satavisha Sarkar (7511555), Upasana Mukherjee (4924993), Christopher J. Johnson (221463), Nicoline C. Frederiks (14051573), Arghya Banerjee (1479340), Jagrut A. Shah (14051570), Ming-Yu Ngai (1530934)   +6 more
core   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

Network meta-analysis of success rate and safety in antibiotic treatments of bronchitis

International Journal of COPD, 2017
Jinghua Wang,1 Haiyang Xu,2 Pan Liu,3 Mingxian Li4 1Pediatric of Rheumatology, Immunology and Allergy, The First Hospital of Jilin University, Changchun, 2Department of Anesthesiology, The First Hospital of Jilin University, Changchun, 3Department of ...
Wang J, Xu H, Liu P, Li M
doaj  

Novel Zwitterionic Polydopamine Nanofiller‐Reinforced Hybrid Membranes With Superior Antifouling Performance for Wastewater Treatment

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work reports one‐pot synthesized novel zwitterionic polydopamine‐silica (ZSiPDA) nanofillers for fabricating PES hybrid ultrafiltration membranes with enhanced hydrophilicity, permeability, and antifouling performance. The optimized membrane achieved over 91% humic acid removal and showed strong potential for municipal wastewater treatment.
Roqaya A. Ismail, Mahendra Kumar, Tarek Lemaoui, Inas M. AlNashef, Shadi W. Hasan, Hassan A. Arafat   +5 more
wiley   +1 more source