Results 221 to 230 of about 68,227 (310)

Oxygen Attachment Dissociation of Protonated Reserpine and Its Analogs

Rapid Communications in Mass Spectrometry, Volume 40, Issue 14, 30 July 2026.
ABSTRACT Rationale Carbon–carbon double bonds are ubiquitous structural motifs in natural products and pose a key challenge in locating their presence in analytes via MS‐based methods. Here, we use the alkaloid reserpine as a model system to examine whether OAD reactions can locate quaternary double bonds embedded in fused multicyclic structures ...
Jack G. Li, Chris J. Bowen, Bun Chan, Adam W. E. Stewart, Hidenori Takahashi, Richard A. J. O'Hair   +5 more
wiley   +1 more source

Uncovering antimicrobial resistance structures in <i>Staphylococcus</i> spp. from companion animals: latent class analysis of isolates from dogs. [PDF]

Front Vet Sci
Castro A, Ayzanoa B, Gutierrez V, Cuicapuza D, Zuñiga R, Ferradas C, Salvatierra G.   +6 more
europepmc   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Tissue and Serum Concentrations of Time‐Dependent Antibiotics in Infected Diabetic Foot Ulcers by Bolus or Continuous Administration: The Randomised DFIATIM Trial

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims The clinical effectiveness of antibiotic (ATB) therapy in patients with infected diabetic foot ulcers (iDFUs) depends on achieving sufficient ATB concentrations in both serum and peripheral tissues. This study evaluated the availability and bactericidal activity of the time‐dependent ATBs—ceftazidime (CTZ) and amoxicillin/clavulanate (AMC)
Radka Jarošíková, Dominika Sojáková, Simona Antalová, Petr Tůma, Jan Polák, Michal Dubský, Andrea Němcová, Veronika Wosková, Pavol Beca, Istvan Modos, Jan Mareš, Jakub Mrázek, Chahrazed Mekadim, Markéta Skružná, Vladimíra Fejfarová   +14 more
wiley   +1 more source

Fluorinative Olefin Bond Functionalization of Selected Functionalized Cycloalkenes

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Palladium‐catalyzed ring olefin bond difunctionalization, through functional group and substrate‐dependent arylfluorination, of selected functionalized cycloalkenes has been studied. Palladium‐catalyzed ring olefin bond difunctionalization through arylfluorination of selected five‐, six‐, and seven‐membered functionalized cycloalkenes has been studied.
Tamás T. Novák, Tamás Holczbauer, Máté Sulyok‐Eiler, Pál T. Szabó, Melinda Nonn, Gábor Turczel, Anas Semghouli, Santos Fustero, Jianlin Han, Gábor Hornyánszky, Loránd Kiss   +10 more
wiley   +1 more source

Matrine Restores Porcine-Origin β-Lactam-Resistant <i>Escherichia coli</i> to Cefepime and Cefquinome: Association with Impaired Biofilm Formation and β-Lactamase Production. [PDF]

Antibiotics (Basel)
Yang B, Yang W, Hu B, Zhao J, Deng H, Yi L, Jian P, Hong Z, Yu D.   +8 more
europepmc   +1 more source

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 7, July 2026.
ABSTRACT Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies for SSTIs. Additionally, we conduct population PK target attainment simulations for varying doses of cephalexin and cefadroxil for Staphylococcus ...
Jonathan H. Ryder, Shawnalyn W. Sunagawa, Nathaniel J. Rhodes, Trevor C. Van Schooneveld, Jeremy E. Tigh, Sean N. Avedissian, Nicolas Cortes‐Penfield   +6 more
wiley   +1 more source

Genomic analysis of the genetic background underlying Streptococcus pneumoniae beta-lactam nonsusceptibility in central Vietnam: increased beta-lactam nonsusceptibility and dynamics of the pbp2x gene. [PDF]

Trop Med Health
Fujii H, Sato M, Nguyen HAT, Vu HTT, Kakiuchi S, Dhoubhadel BG, Nakamura S, Motooka D, Ogura Y, Nakano S, Parry CM, Morimoto K, Yoshida LM, Anh DD, Hayashi T, Iida T, Ariyoshi K.   +16 more
europepmc   +1 more source

The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors

Protein Science, Volume 35, Issue 7, July 2026.
Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley   +1 more source

Phenotypic and genotypic characterization of HMB-3, a metallo-beta-lactamase from Pseudomonas asiatica. [PDF]

J Antimicrob Chemother
Findlay J, Shaw JM, Nordmann P, Hinchliffe P, Laffer EB, Born Y, Seth-Smith HMB, Egli A, Pfennigwerth N, Spencer J, Poirel L.   +10 more
europepmc   +1 more source