Results 141 to 150 of about 360,868 (176)

Human lactase and the molecular basis of lactase persistence

Biochemical Genetics, 1985
Human lactase purified from detergent extracts of the total membrane fraction of postmortem jejunum by means of monoclonal immunoadsorbent chromatography appears to be a dimer of subunits identical in Mr (160K). Trypsin or papain removes a small hydrophobic anchoring peptide from each subunit to give a hydrophilic enzyme which no longer interacts with ...
J, Potter, M W, Ho, H, Bolton, A J, Furth, D M, Swallow, B, Griffiths   +5 more
openaire   +2 more sources

The influence of Scandinavian presence on Greenlandic lactase persistence

Scandinavian Journal of Gastroenterology, 2022
The study aims to estimate the prevalence of lactase non-persistence (LNP) among Greenlandic Inuit and Scandinavians living in Nuuk and East Greenland. The C to T transition in LCT - 13910 (rs4988235) is an autosomal inherited variant that provides the ability to lifelong lactase production, necessary to digest milk.
Símun Niclasen, Stig Andersen, Nadja Albertsen, Henrik Bygum Krarup   +3 more
openaire   +3 more sources

Lactase haplotype frequencies in Caucasians: association with the lactase persistence/non‐persistence polymorphism

Annals of Human Genetics, 1998
A genetic polymorphism is responsible for determining that some humans express lactase at high levels throughout their lives and are thus lactose tolerant, while others lose lactase expression during childhood and are lactose intolerant. We have previously shown that this polymorphism is controlled by an element or elements which act in cis to the ...
Harvey, CB, Hollox, EJ, Poulter, M, Wang, Y, Rossi, M, Auricchio, S, Iqbal, TH, Cooper, BT, Barton, R, Sarner, M, Korpela, R, Swallow, DM   +11 more
openaire   +4 more sources

Lactose digestion and the evolutionary genetics of lactase persistence

Human Genetics, 2008
It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interest of investigators from different disciplines.
Dallas M Swallow, Mark Thomas, Yuval Itan   +2 more
exaly   +3 more sources

The -13914G>A variant upstream of the lactase gene (LCT) is associated with lactase persistence/non-persistence

Scandinavian Journal of Clinical and Laboratory Investigation, 2010
Adult-type hypolactasia (lactase non-persistence) is a common cause of gastrointestinal symptoms. Several DNA sequence variants have been identified for the lactase-persistence/non-persistence (LP/LNP), the most common being the C to T residing -13910 bp upstream of the lactase gene (LCT).
Yulia, Khabarova, Suvi, Torniainen, Erkki, Savilahti, Mauri, Isokoski, Kari, Mattila, Irma, Järvelä   +5 more
openaire   +2 more sources

Lactase persistence in central Asia: phenotype, genotype, and evolution.

Human Biology, 2011
International audienceThe aim of the present study is to document the evolution of the lactase persistence trait in Central Asia, a geographical area that is thought to have been a region of long-term pastoralism.
Laure Ségurel, Frédéric Austerlitz, Evelyne Heyer   +2 more
exaly   +2 more sources

Persistence of high intestinal lactase activity in Pakistan

Human Genetics, 1983
In order to determine the incidence of persistence of high intestinal lactase activity (PLA) in a Pakistani human population, 53 probands belonging to the Punjabi ethnic group were examined using a lactose tolerance test. The incidence of PLA in the sample was found to be 55%, which has been compared with the incidence in other ethnic groups racially ...
H, Abbas, M, Ahmad
openaire   +2 more sources

The Role of Lactase Persistence in Precolonial Development

SSRN Electronic Journal, 2012
This paper argues that a genetic adaptation to the Neolithic Revolution led to differential levels of development in the precolonial era. The ability to digest milk, or to be lactase persistent, is conferred by a gene variant that is unequally distributed across the Old World.
openaire   +1 more source

Genetics of Lactase Persistence and Lactose Intolerance

Annual Review of Genetics, 2003
▪ Abstract  The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase.
openaire   +2 more sources

Microsatellite variation and evolution of human lactase persistence

Human Genetics, 2005
The levels of haplotype diversity within the lineages defined by two single-nucleotide polymorphisms (SNPs) (-13910 C/T and -22018 G/A) associated with human lactase persistence were assessed with four fast-evolving microsatellite loci in 794 chromosomes from Portugal, Italy, Fulbe from Cameroon, São Tomé and Mozambique.
Coelho M., LUISELLI, DONATA, Bertorelle G., Lopes A. I., Seixas S., Destro Bisol G., Rocha J.   +6 more
openaire   +3 more sources