Results 141 to 150 of about 345,367 (170)
Association of Lactase Persistence Genotypes (rs4988235) and Ethnicity with Dairy Intake in a Healthy U.S. Population [PDF]
Nutrients, 2019 Charles Stephensen +2 more
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Annals of Human Genetics, 1998
A genetic polymorphism is responsible for determining that some humans express lactase at high levels throughout their lives and are thus lactose tolerant, while others lose lactase expression during childhood and are lactose intolerant. We have previously shown that this polymorphism is controlled by an element or elements which act in cis to the ...
Harvey, CB +11 more
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A genetic polymorphism is responsible for determining that some humans express lactase at high levels throughout their lives and are thus lactose tolerant, while others lose lactase expression during childhood and are lactose intolerant. We have previously shown that this polymorphism is controlled by an element or elements which act in cis to the ...
Harvey, CB +11 more
openaire +4 more sources
Scandinavian Journal of Clinical and Laboratory Investigation, 2010
Adult-type hypolactasia (lactase non-persistence) is a common cause of gastrointestinal symptoms. Several DNA sequence variants have been identified for the lactase-persistence/non-persistence (LP/LNP), the most common being the C to T residing -13910 bp upstream of the lactase gene (LCT).
Yulia, Khabarova +5 more
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Adult-type hypolactasia (lactase non-persistence) is a common cause of gastrointestinal symptoms. Several DNA sequence variants have been identified for the lactase-persistence/non-persistence (LP/LNP), the most common being the C to T residing -13910 bp upstream of the lactase gene (LCT).
Yulia, Khabarova +5 more
openaire +2 more sources
Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden
International Journal of Cancer, 2005 Ovarian carcinoma is the fourth most common cause of cancer death in women. The cause and pathogenesis of this disease has remained obscure. Galactose, the hydrolyzing product of the milk sugar lactose, has been hypothesized to be toxic to ovarian ...
Irma Järvelä, Mikko Kuokkanen
exaly +2 more sources
Persistence of high intestinal lactase activity in Pakistan
Human Genetics, 1983In order to determine the incidence of persistence of high intestinal lactase activity (PLA) in a Pakistani human population, 53 probands belonging to the Punjabi ethnic group were examined using a lactose tolerance test. The incidence of PLA in the sample was found to be 55%, which has been compared with the incidence in other ethnic groups racially ...
H, Abbas, M, Ahmad
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The Role of Lactase Persistence in Precolonial Development
SSRN Electronic Journal, 2012This paper argues that a genetic adaptation to the Neolithic Revolution led to differential levels of development in the precolonial era. The ability to digest milk, or to be lactase persistent, is conferred by a gene variant that is unequally distributed across the Old World.
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Genetics of Lactase Persistence and Lactose Intolerance
Annual Review of Genetics, 2003▪ Abstract The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase.
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Lactase non-persistent genotype distribution in Italy
Minerva Gastroenterology, 2017Adult-type hypolactasia is a frequent condition of lactose malabsorption; in Europe the distribution of adult-type hypolactasia have been shown to display a North-South gradient. Genotyping for LCT-13910 C>T polymorphism has been proposed as a useful diagnostic marker of adult-type hypolactasia.
Cristina, Zadro +4 more
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Hypolactasia and Lactase Persistence Historical Review and the Terminology
Scandinavian Journal of Gastroenterology, 1994Lactase (more precisely lactase-phlorizin hydrolase) is located in the brush border of the small intestinal enterocytes and is responsible for the hydrolysis of dietary lactose. The earliest studies on lactase activity in mammals were published around the turn of the century.
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EVOLUTION OF LACTASE PERSISTENCE
The Lancet, 1989S F, Hoegerman, R A, Schenck
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