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Lactase Non-persistence and Lactose Intolerance

Current Gastroenterology Reports, 2017
To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence.
Theodore M, Bayless   +2 more
openaire   +4 more sources

Genetics of Lactase Persistence and Lactose Intolerance

Annual Review of Genetics, 2003
▪ Abstract  The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase.
Dallas M Swallow
openaire   +4 more sources

On the Evolution of Lactase Persistence in Humans

Annual Review of Genomics and Human Genetics, 2017
Lactase persistence—the ability of adults to digest the lactose in milk—varies widely in frequency across human populations. This trait represents an adaptation to the domestication of dairying animals and the subsequent consumption of their milk. Five variants are currently known to underlie this phenotype, which is monogenic in Eurasia but mostly ...
Ségurel, Laure, Bon, Céline
openaire   +5 more sources

Lactose digestion and the evolutionary genetics of lactase persistence

Human Genetics, 2008
It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interest of investigators from different disciplines.
Catherine J E, Ingram   +4 more
openaire   +4 more sources

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