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Lactase restriction and lactase persistence: a study of sri lankans and a paediatric population
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On the Evolution of Lactase Persistence in Humans
Annual Review of Genomics and Human Genetics, 2017 Lactase persistence—the ability of adults to digest the lactose in milk—varies widely in frequency across human populations. This trait represents an adaptation to the domestication of dairying animals and the subsequent consumption of their milk. Five variants are currently known to underlie this phenotype, which is monogenic in Eurasia but mostly ...
Celine Bon, Laure Segurel
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Microsatellite variation and evolution of human lactase persistence
Human Genetics, 2005 The levels of haplotype diversity within the lineages defined by two single-nucleotide polymorphisms (SNPs) (-13910 C/T and -22018 G/A) associated with human lactase persistence were assessed with four fast-evolving microsatellite loci in 794 chromosomes from Portugal, Italy, Fulbe from Cameroon, São Tomé and Mozambique.
Rocha J +2 more
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Lactase Non-persistence and Lactose Intolerance
Current Gastroenterology Reports, 2017To evaluate the clinical and nutritional significance of genetically determined lactase non-persistence and potential lactose and milk intolerance in 65-70% of the world's adult population.Milk consumption is decreasing in the USA and is the lowest in countries with a high prevalence of lactase non-persistence.
David M Paige
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Lactose digestion and the evolutionary genetics of lactase persistence
Human Genetics, 2008It has been known for some 40 years that lactase production persists into adult life in some people but not in others. However, the mechanism and evolutionary significance of this variation have proved more elusive, and continue to excite the interest of investigators from different disciplines.
Dallas Swallow +2 more
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Low prevalence of lactase persistence in Neolithic South-West Europe
European Journal of Human Genetics, 2012 Contains fulltext : 108572.pdf (Publisher’s version ) (Open Access)The ability of humans to digest the milk component lactose after weaning requires persistent production of the lactose-converting enzyme lactase.
Rosa Fregel, Santos Alonso
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Lactase Persistence in Central Asia: Phenotype, Genotype, and Evolution
Human Biology, 2011 International audienceThe aim of the present study is to document the evolution of the lactase persistence trait in Central Asia, a geographical area that is thought to have been a region of long-term pastoralism.
Laure Segurel +2 more
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Human lactase and the molecular basis of lactase persistence
Biochemical Genetics, 1985Human lactase purified from detergent extracts of the total membrane fraction of postmortem jejunum by means of monoclonal immunoadsorbent chromatography appears to be a dimer of subunits identical in Mr (160K). Trypsin or papain removes a small hydrophobic anchoring peptide from each subunit to give a hydrophilic enzyme which no longer interacts with ...
J, Potter +5 more
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The influence of Scandinavian presence on Greenlandic lactase persistence
Scandinavian Journal of Gastroenterology, 2022The study aims to estimate the prevalence of lactase non-persistence (LNP) among Greenlandic Inuit and Scandinavians living in Nuuk and East Greenland. The C to T transition in LCT - 13910 (rs4988235) is an autosomal inherited variant that provides the ability to lifelong lactase production, necessary to digest milk.
Símun Niclasen +3 more
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