Results 131 to 140 of about 708,087 (381)

The Lactate/Pyruvate Ratio of Metabolic Modulation Using Glucose Insulin Kalium and Lactate Solution and Their Effect on Functional Mechanical Recovery of the Isolated Perfused Heart [PDF]

open access: yes, 2009
Metabolic modulation with Glucose Insulin Kalium (GIK) solution has beenreally well known in their capacity to improve post ischemic heart function. In this regardGIK intervention on post operative Coronary Artery Bypass Graft (CABG) can improveheart ...
Arhya, I. N. (I)   +3 more
core  

Somatotropin and Lactation

open access: yesJournal of Dairy Science, 1987
Somatotropin, which can now be produced by biotechnology, could have an enormous impact on the dairy industry. Milk yield has been increased up to 40% with daily injections of somatotropin. Cows adjust their nutrient intake to support this increase. Somatotropin does not adversely affect cows' health, although all studies to date have been for less ...
C.J. Peel, Dale E. Bauman
openaire   +3 more sources

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau   +12 more
wiley   +1 more source

Herbal Formula Yi‐Fei‐Jie‐Du‐Tang Regulates Epithelial‐Mesenchymal Transition and Vasculogenic Mimicry in Lung Cancer via HIF1A‐Mediated Ferroptosis

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Yi‐Fei‐Jie‐Du‐Tang (YFJDT), a traditional Chinese medicine, has shown potential in lung cancer treatment by targeting key pathways. This study explores the mechanisms of YFJDT using bioinformatics, xenograft models, and A549 cells, demonstrating that YFJDT downregulates HIF1A, promotes ferroptosis, and inhibits epithelial‐mesenchymal transition (EMT ...
Shanshan Wang   +6 more
wiley   +1 more source

Probing lactate exchange and compartmentation in Gray Matter via time-dependent diffusion-weighted MRS [PDF]

open access: yesarXiv
Lactate is crucial in the brain, as it is involved in neuronal activity and memory formation. This is thought to be related to the astrocyte-neuron lactate shuttle hypothesis (ANLS), which has been debated for 30 years, not least because it is difficult to measure lactate compartmentation and exchange in vivo.
arxiv  

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

open access: yesAdvanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim   +3 more
wiley   +1 more source

A mathematical study of the interaction between oxygen and lactate in an in-vivo and in-vitro tumor [PDF]

open access: yesarXiv
Micro-environmental acidity is a common feature of the tumor. One of the causes behind tumor acidity is lactate production by hypoxic cells of the tumor. Hypoxia is a direct result of the establishment of oxygen gradients. It is commonly observed in the tumor in an in-vitro experimental setup and also in-vivo situation.
arxiv  

The Regulation of Trace Metal Elements in Cancer Ferroptosis

open access: yesAdvanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang   +5 more
wiley   +1 more source

Filtering Microarray Correlations by Statistical Literature Analysis Yields Potential Hypotheses for Lactation Research [PDF]

open access: yesLing, MHT, Lefevre, C, Nicholas, KR. 2008. Filtering Microarray Correlations by Statistical Literature Analysis Yields Potential Hypotheses for Lactation Research. The Python Papers 3(3): 4, 2009
Our results demonstrated that a previously reported protein name co-occurrence method (5-mention PubGene) which was not based on a hypothesis testing framework, it is generally statistically more significant than the 99th percentile of Poisson distribution-based method of calculating co-occurrence. It agrees with previous methods using natural language
arxiv  

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