Results 231 to 240 of about 778,516 (343)

Utility of serum lactate to predict drug-overdose fatality

, 2010
Alex F. Manini, Ashish Kumar, Dean Olsen, David Vlahov, Robert S. Hoffman   +4 more
openalex   +1 more source

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Integrated Mendelian Randomization and Single-Cell RNA Sequencing Analyses Reveal Lactate Metabolism as a Key Pathway in COVID-19-Induced Pulmonary Fibrosis. [PDF]

Can Respir J
Zhang X, Jia L, Yeziya T, Yang S, Chen M, Mo Y, Tong X, Zhang L.   +7 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer. [PDF]

NPJ Digit Med
Tan Y, Tan W, Liang Y, Long Y, Chen S, Hu Q, Ou Y, Fu J, Chen H, Ren F, Ye J, Zhou Q, Li S, He X, Wang Q, Shen Y, Lu H, Wu D, Gao A, Chen X, Li Y.   +20 more
europepmc   +1 more source

Copper (II)–Lactate Complexes in Cu₂O Electrodeposition Baths: Stability of the Complexes and Aging of the Baths

Kiho Nishioka, M. Okada, Ryo Kanzaki, Kazuhiro Fukami, Kuniaki Murase   +4 more
openalex   +1 more source

Expression, Characterization, and Immobilization of a Novel D-Lactate Dehydrogenase from Salinispirillum sp. LH 10-3-1 [PDF]

Jianguo Liu, X Y Jiang, Yaru Zheng, Kaixuan Li, Rui-Xin Zhang, Jingping Xu, Zhe Wang, Yuxuan Zhang, Haoran Yin, Jing Li   +9 more
openalex   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Lactate increases oxygen unloading of preconditioned blood from male elite breath-hold divers. [PDF]

Physiol Rep
Kjeld T, Hansen EG, Arendrup HC, Højberg J, Nedergaard A, Krag T, Vissing J.   +6 more
europepmc   +1 more source

Effects of Vitamin A, D3, E, and Selenium Supplementation on Reproductive Performance in Lactating Kilis Goats Applied with Estrus Synchronization During the Breeding Season

Mehmet Dede Tiken, Mustafa Kemal Sarıbay, Gökhan Uyanık   +2 more
openalex   +2 more sources