The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]
, 2015 The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio +3 more
core +1 more source
Haematologica, 2010 Primary myelofibrosis shows histological and pathogenetic overlap with essential thrombocythemia and polycythemia vera. Several diagnostic classifications have been proposed for primary myelofibrosis, although little is known about their clinical utility.
Philip A. Beer +2 more
doaj +1 more source
The D-Lactate Dehydrogenase from Sporolactobacillus inulinus Also Possessing Reversible Deamination Activity. [PDF]
PLoS ONE, 2015 Hydroxyacid dehydrogenases are responsible for the conversion of 2-keto acids to 2-hydroxyacids and have a wide range of biotechnological applications.
Lingfeng Zhu +4 more
doaj +1 more source
Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy
Cancer Medicine, 2018 Elevated glycolysis remains a universal and primary character of cancer metabolism, which deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) facilitates glycolytic process by converting pyruvate to lactate.
Yangbo Feng +5 more
semanticscholar +1 more source
Biosensors based on electrochemical lactate detection: A comprehensive review
Biochemistry and Biophysics Reports, 2016 Lactate detection plays a significant role in healthcare, food industries and is specially necessitated in conditions like hemorrhage, respiratory failure, hepatic disease, sepsis and tissue hypoxia. Conventional methods for lactate determination are not
Kavita Rathee +3 more
doaj +1 more source
A STUDY OF SERUM LACTATE AS A PREDICTOR OF SEVERITY IN DENGUE INFECTION
National Journal of Medical Research, 2023 Background: Dengue infections caused by the four antigenically distinct dengue virus serotypes (DENV1, DENV2, DENV3, DENV4) of the family Flaviviridae are the most major arboviral diseases in humans in terms of geographic spread, morbidity, and ...
Meet Ladani +4 more
doaj +1 more source
Salivary pH, calcium, phosphorus and selected enzymes in healthy dogs: A pilot study [PDF]
, 2017 Background Saliva in dogs, as in humans, is a complex fluid secreted by different salivary glands in the oral cavity to protect the oral mucosa and teeth.
Badon, Tamara +5 more
core +2 more sources
Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression
Nature CommunicationsAbundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs macrophage migration and ...
Fatima Khan +14 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2019 Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress–induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A ...
B. Cui +32 more
semanticscholar +1 more source
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]
, 2019 Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C. +3 more
core +1 more source