Results 81 to 90 of about 785,757 (422)

Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state

Revista Brasileira de Hematologia e Hemoterapia, 2015
Objective: This study aimed to evaluate the influence of fetal hemoglobin (Hb F) on hemolysis biomarkers in sickle cell anemia patients. Methods: Fifty adult sickle cell anemia patients were included in the study.
Juliane Almeida Moreira, Marília Rocha Laurentino, Rosângela Pinheiro Gonçalves Machado, Maritza Cavalcante Barbosa, Ronaldo Pinheiro Gonçalves, Amanda de Menezes Mota, Lilianne Brito da Silva Rocha, Alice Maria Costa Martins, Alcínia Braga de Lima Arruda, Iêda Pereira de Souza, Romélia Pinheiro Gonçalves   +10 more
doaj   +1 more source

BIOMARKERS OF SUBCLINICAL MASTITIS IN THE MAMMARY GLAND OF COWS [PDF]

Biotechnologia Acta, 2017
The aim of the study was to create an algorithm for controlling subclinical forms of mastitis of cows on the basis of determining the activity of lactate dehydrogenase and the number of somatic cells in milk.
V. R. Mazurenko, O. V. Manchulyak
doaj   +1 more source

Harnessing Lactate Metabolism for Radiosensitization

Frontiers in Oncology, 2021
Cancer cells rewire their metabolism to promote cell proliferation, invasion, and metastasis. Alterations in the lactate pathway have been characterized in diverse cancers, correlate with outcomes, and lead to many downstream effects, including ...
Kevin X. Liu, Emily Everdell, Sharmistha Pal, Daphne A. Haas-Kogan, Michael G. Milligan   +4 more
doaj   +1 more source

Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma

British Journal of Cancer, 2016
Background:Treatment with programmed death receptor-1 (PD-1) antibodies is associated with high response rates in patients with advanced melanoma. Reliable markers for early response and outcome are still sparse.Methods:We evaluated 66 consecutive ...
S. Diem, B. Kasenda, L. Spain, J. Martín-Liberal, J. Martín-Liberal, R. Marconcini, M. Gore, J. Larkin   +7 more
semanticscholar   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Cystatin-C is an independent prognostic factor for survival in multiple myeloma and is reduced by bortezomib administration

Haematologica, 2009
Background Renal impairment is a common complication of multiple myeloma. Cystatin-C is considered an accurate marker of glomerular filtration rate in several renal disorders.
Evangelos Terpos, Eirini Katodritou, Evangelos Tsiftsakis, Efstathios Kastritis, Dimitrios Christoulas, Anastasia Pouli, Eurydiki Michalis, Evgenia Verrou, Konstantinos Anargyrou, Konstantinos Tsionos, Meletios A. Dimopoulos, Konstantinos Zervas   +11 more
doaj   +1 more source

Expression of Lactate Dehydrogenase in Aspergillus niger for L-Lactic Acid Production. [PDF]

PLoS ONE, 2015
Different engineered organisms have been used to produce L-lactate. Poor yields of lactate at low pH and expensive downstream processing remain as bottlenecks.
Khyati K Dave, Narayan S Punekar
doaj   +1 more source

Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.

Cancer Research, 2017
Immunometabolism is emerging as a critical determinant of cancer pathophysiology. In this study, we explored the contributions of macrophage-expressed lactate dehydrogenase-A (LDH-A) to tumor formation in a K-Ras murine model of lung carcinoma.
P. Seth, E. Csizmadia, Andreas Hedblom, M. Vuerich, Han Xie, Mailin Li, M. Longhi, B. Wegiel   +7 more
semanticscholar   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Journal of Medicinal Chemistry, 2017
We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high-throughput screening paradigm facilitated hit identification, while ...
Ganesha Rai, K. Brimacombe, B. Mott, D. Urban, Xin Hu, Shyh-Ming Yang, Tobie D. Lee, Dorian M. Cheff, Jennifer Kouznetsova, G. Benavides, Katherine Pohida, E. J. Kuenstner, D. Luci, C. Lukacs, D. Davies, D. Dranow, Huahua Zhu, G. Sulikowski, William J. Moore, Gordon M. Stott, A. Flint, M. Hall, V. Darley-Usmar, L. Neckers, C. Dang, A. Waterson, A. Simeonov, A. Jadhav, D. Maloney   +28 more
semanticscholar   +1 more source