Results 91 to 100 of about 930,544 (280)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

A Comparison Of Wearable Lactate Threshold Technology To Accepted Methods Of Lactate Threshold Determination

Medicine & Science in Sports & Exercise, 2021
Lindsay Parisi, Jessica Alsup, Brittany Benoit, Danielle Patton, Brianna DiMattia   +4 more
openaire   +2 more sources

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

Admission lactate and in-hospital mortality in elderly patients with sepsis receiving invasive mechanical ventilation: a multicenter retrospective cohort study

European Journal of Medical Research
Background Elderly patients with sepsis requiring invasive mechanical ventilation are at high risk of death. However, the prognostic value of admission lactate in this specific population remains incompletely characterized.
Shunzhong Jing, Liping Jiang, Anyuan Liu, Jiamei Liang, Xiaoqiang Sun, Yunan Lin   +5 more
doaj   +1 more source

Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis

Singapore Medical Journal
Introduction: This study aimed to determine the diagnostic value of interleukin (IL)-6, IL-8, IL-17, tumour necrosis factor-alpha (TNF-α) and D-lactate levels in the cerebrospinal fluid (CSF) of nosocomial meningitis patients.
Sibel Yorulmaz Goktas, Arzu Yılmaztepe Oral, Emel Yılmaz, Emin Halis Akalın, Furkan Guvenc, Guven Ozkaya, Hasan Kocaeli, Seref Dogan, Selcuk Yılmazlar, Haluk Barbaros Oral   +9 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Predictive value of lactate threshold concepts.

, 2018
Predictive value of lactate threshold concepts.
Jules A. A. C. Heuberger (5963654), Wouter A. S. de Muinck Keizer (5963663), Yuri Mejia Miranda (5808437), Adam F. Cohen (5963666), Frederik E. Stuurman (5963660), Pim Gal (5963657)   +5 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Mean lactate threshold concept power output.

, 2018
Mean lactate threshold concept power output.
Jules A. A. C. Heuberger (5963654), Wouter A. S. de Muinck Keizer (5963663), Yuri Mejia Miranda (5808437), Adam F. Cohen (5963666), Frederik E. Stuurman (5963660), Pim Gal (5963657)   +5 more
core   +1 more source

Sweat lactate sensor for detecting anaerobic threshold in heart failure: a prospective clinical trial (LacS-001)

Scientific Reports
A simple method for determining the anaerobic threshold in patients with heart failure (HF) is needed. This prospective clinical trial (LacS-001) aimed to investigate the safety of a sweat lactate-monitoring sensor and the correlation between lactate ...
Yoshinori Katsumata, Yuki Muramoto, Noriyuki Ishida, Ryo Takemura, Kengo Nagashima, Takenori Ikoma, Naoto Kawamatsu, Masaru Araki, Ayumi Goda, Hiroki Okawara, Tomonori Sawada, Yumiko Kawakubo Ichihara, Osamu Hattori, Koki Yamaoka, Yuta Seki, Toshinobu Ryuzaki, Hidehiko Ikura, Daisuke Nakashima, Takeo Nagura, Masaya Nakamura, Kazuki Sato, Yasuyuki Shiraishi   +21 more
doaj   +1 more source