Results 101 to 110 of about 930,544 (280)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Changes in blood lactate concentration during active recovery at sub-lactate threshold, lactate threshold, and supra-lactate threshold exercise intensities.

, 1991
The purpose of this investigation was to identify the intensity of recovery exercise, relevant to endurance event performance, that would result in the most rapid times for half decrease in blood lactate concentration, following 2 minutes of cycling at ...
Weihrer, Sylvia J.
core  

Cronbach’s alpha for each lactate threshold concept.

, 2018
Cronbach’s alpha for each lactate threshold concept.
Jules A. A. C. Heuberger (5963654), Wouter A. S. de Muinck Keizer (5963663), Yuri Mejia Miranda (5808437), Adam F. Cohen (5963666), Frederik E. Stuurman (5963660), Pim Gal (5963657)   +5 more
core   +1 more source

Physiological Key Determinants of Elite Open-Water Swimmers

Physiologia
This study describes the relationships between different physiological measurements and combinations of critical velocity and performance in elite open-water swimmers. A total of 15 international male open-water swimmers performed a 5 × 200 m front crawl
Robin Pla, Yannis Raineteau, Xavier Barbier, Anaël Aubry   +3 more
doaj   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Agreement between heart rate variability‐derived and lactate/ventilatory thresholds during a 4‐min stepwise incremental cycling test in male adults

Physiological Reports
Accurate exercise intensity thresholds are key for endurance training prescription. The non‐linear heart rate (HR) variability (HRV) index DFAa1 has been proposed as a threshold determination marker, with DFAa1 values of 0.75 (HRVT1) and 0.5 (HRVT2 ...
Anton Olieslagers, Yoram Müller‐Jabusch, Margot Vancoillie, Emma Delen, Toon de Beukelaar   +4 more
doaj   +1 more source

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Tempo de exaustão na máxima fase estável de lactato em protocolo contínuo e intermitente no ciclismo [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-graduação em Educação Física, Florianópolis, 2011A intensidade da máxima fase estável de lactato (wMLSS) representa o índice fisiológico padrão ouro ...
Grossl, Talita
core  

Mesoporous‐Shell Monolayer Plasmonic Architecture Enables Quantitative and Decision‐Guided SERS

Advanced Science, EarlyView.
Mesoporous‐shell‐regulated molecular transport combined with monolayer hotspot determinism transforms surface‐enhanced Raman spectroscopy (SERS) from ultrasensitive detection into quantitative and decision‐guided molecular sensing. ABSTRACT Quantitative surface‐enhanced Raman spectroscopy (SERS) has long been impeded by stochastic hotspot formation ...
Guangyao Huang, Ying Wang, Yue Fang, Jingyuan Shao, Sensen Hao, Mancun Zhao, Yuan Yao, Junping Wang, Wei Zhou, Hongzhi Wang   +9 more
wiley   +1 more source

AI‐Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High‐Contrast HER2‐Positive Tumor Imaging

Advanced Science, EarlyView.
A novel targeted and pH‐responsive MRI contrast agent was integrated with a 3D nnU‐Net deep learning framework to enable accurate delineation of tumor boundary morphology in HER2‐positive breast cancer imaging. ABSTRACT Breast cancer continues to be a leading cause of cancer‐related mortality in women globally, where precise diagnosis and clear tumor ...
Jiaying Zheng, Yi Zhu, Xinrui Li, Sunxian Dai, Xiangyuan Ma, Hongwei Lu, Zhongling Wang, Benqing Zhou   +7 more
wiley   +1 more source