Results 111 to 120 of about 930,544 (280)

Unlocking high-intensity performance thresholds through ventilatory signatures in the ECG

Scientific Reports
A ubiquitously available and accurate non-invasive ventilatory threshold assessment (NIVA) would substantially improve real-world performance assessment evaluation in both clinical and elite sports settings.
V. Heinz, N. Pilz, L. Fesseler, T. Lindner, L. Malotka, O. Opatz, D. Blottner, O. Anosov, A. Patzak, Michael Fähling, T. L. Bothe   +10 more
doaj   +1 more source

Stride-to-stride variability and fluctuations at intensities around lactate threshold in distance runners. [PDF]

Heliyon, 2023
Watanabe T, Kondo S, Kakinoki K, Fukusaki C, Hatta H.   +4 more
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Modeling lactate threshold in young squad athletes: influence of sex, maximal oxygen uptake, and cost of running. [PDF]

Eur J Appl Physiol, 2023
Ji S, Keller S, Zwingmann L, Wahl P.
europepmc   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Validation of aerobic threshold assessment using a sweat lactate sensor during arm crank exercise by healthy adults

Physiological Reports
Assessment of the aerobic threshold (AeT) using a sweat lactate sensor has been validated primarily during lower limb exercise. This study aimed to examine whether sweat‐based AeT assessment is also applicable during upper limb exercise.
Tomonori Sawada, Hiroki Okawara, Kazuki Minami, Shintaro Narushima, Ayaka Shiratori, Yoshinori Katsumata, Masaya Nakamura, Takeo Nagura, Daisuke Nakashima   +8 more
doaj   +1 more source

Lactate Threshold and Psychomotor Fatigue Threshold in Hot Conditions: Suggestions for Soccer Players Participating in the Qatar World Cup 2022. [PDF]

Int J Environ Res Public Health, 2022
Konefał M, Chmura J, Charmas M, Kotowska J, Błażejczyk K, Chmura P.   +5 more
europepmc   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Threshold estimation in running using dynamical correlations of RR intervals

Physiological Reports
We study the estimation of aerobic threshold (AeT) and anaerobic threshold (AnT) using dynamical detrended fluctuation analysis (DDFA). Conventionally, the thresholds are estimated in laboratory settings, where the subject performs an incremental ...
Matias Kanniainen, Vesa Laatikainen‐Raussi, Teemu Pukkila, Krista Vohlakari, Esa Hynynen, Johanna K. Ihalainen, Esa Räsänen   +6 more
doaj   +1 more source