Results 111 to 120 of about 6,423 (261)

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Peak Lactate During the First Postoperative Day Predicts 90-Day Graft Loss After Liver Transplantation. [PDF]

J Clin Med
Lai Q, Cutic B, Iannello L, Hanzek I, Melandro F, Baronica R, Mennini G, Sesa V, Rossi M, Mrzljak A.   +9 more
europepmc   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Perioperative Carbon Dioxide Gap Following Crystalloid and Colloid Therapy in Neurosurgical Patients: A Randomised Comparative Study

JK Science
Background: The carbon dioxide gap (CO2‚ gap) is a flow-dependent variable inversely related to cardiac output and has emerged as a potential marker of circulatory adequacy.
Manisha Manohar, Prashant Kumar, Smita Chettri, Kiranpreet Kaur, Somedha Vashishth, Anshul   +5 more
doaj  

First experience of hemadsorption with HA60 cartridges in newborns and small infants with septic shock: a case series. [PDF]

Front Pediatr
Bottari G, Maccarrone C, Torelli A, Di Nardo M, Mazzeo AT, Cecchetti C, Guzzo I.   +6 more
europepmc   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Bending‐Resistant Intimate 3D Graphene–Metal Heterojunctions for Highly Sensitive and Robust Flexible Sensors

Advanced Science, EarlyView.
A reservoir‐guided silver‐nanoparticle soldering strategy is developed for bending‐resistant 3D graphene–metal heterojunctions. Controlled hot‐plate evaporation confines conductive ink within the metal reservoir, suppressing spreading and protecting the LIG interface from deformation‐induced fracture.
Saeyoung Park, Yoo‐Kyum Shin, Na‐Kyoung Yang, Gyeong‐Hwan Park, Somi Lee, Min‐Ho Seo   +5 more
wiley   +1 more source

Cardiogenic shock in the course of myocardial infarction: the results of the Shock-POL registry. [PDF]

ESC Heart Fail
Wybraniec MT, Sufryd A, Cichoń M, Tokarek T, Dykla D, Zeliaś A, Holcman K, Szczepara S, Kowalik R, Fojt A, Kapłon-Cieślicka A, Błaziak M, Sokolski M, Tkaczyszyn M, Kuliczkowski W, Gąsior P, Pawlus P, Wojakowski W, Morawiec B, Kawecki D, Kułach A, Smolka G, Janas A, Mizia-Stec K, Wita K.   +24 more
europepmc   +1 more source

Solution Thermodynamics of Methyl, Ethyl, Propyl, and Butyl Lactates in High-Pressure CO₂. [PDF]

ACS Omega
Behera US, Shim J, Lee HS, Byun HS.
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source