Results 181 to 190 of about 77,943 (339)

Accidental dexmedetomidine overdose in preterm newborns: a report of 3 cases. [PDF]

Ital J Pediatr
Paviotti G, D'Agostini M, Mauro I, Bortolotti F, Gottardo R, Pittini C.   +5 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Zeolite-catalyzed biomass conversion to fuels and chemicals [PDF]

, 2011
Andersen, Simon I., Christensen, Claus H., Osmundsen, Christian Mårup, Taarning, Esben, Voss, Bodil, Yang, Xiaobo   +5 more
core   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Continuous Production of Methyl Lactate from Hemicellulosic Sugars: Identifying and Sorting out Sn-USY-Based Catalyst Deactivation. [PDF]

ACS Sustain Chem Eng
Jiménez-Martín JM, El Tawil-Lucas M, Orozco-Saumell A, López Granados M, Pulido JA, Mariscal R, Moreno J, García A, Iglesias J.   +8 more
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Correlation between metabolite concentrations in the frontal lobes, determined using ¹H-MRS, and IQ in children with foetal alcohol spectrum disorder. [PDF]

Pol J Radiol
Urbanik A, Jadczak-Szumiło T, Ostrogórska M.   +2 more
europepmc   +1 more source

Supplementary Figure S9 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer [PDF]

Nadia Boufaied, Paolo Chetta, Tarek Hallal, Stefano Cacciatore, Daniela Lalli, Carole Luthold, Kevin Homsy, Eddie L. Imada, Sudeepa Syamala, Cornelia Photopoulos, Anna Di Matteo, Anna de Polo, Alessandra Maria Storaci, Ying Huang, Francesca Giunchi, Patricia A. Sheridan, Gregory Michelotti, Quang‐Dé Nguyen, Xin Zhao, Yang Liu, Elai Davicioni, Daniel E. Spratt, Simone Sabbioneda, Giovanni Maga, Lorelei A. Mucci, Claudia Ghigna, Luigi Marchionni, Lisa M. Butler, Leigh Ellis, François Bordeleau, Massimo Loda, Valentina Vaira, David P. Labbé, Giorgia Zadra   +33 more
openalex   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Maternal Characteristics Related to Post Partum Body Composition Changes Among Lactating and Non-Lactating Mothers [PDF]

, 1989
Nathalie Guindre
openalex