Results 241 to 250 of about 77,943 (339)

The Effect of Intraoperative Hypothermia on Anastomotic Leakage After Esophagectomy. [PDF]

Cancers (Basel)
Cinelli L, Turi S, Puccetti F, Lee YH, Rosati R, Elmore U, On Behalf Of The Osr CCeR Collaborative Group.   +6 more
europepmc   +1 more source

Effects of Vitamin A, D3, E, and Selenium Supplementation on Reproductive Performance in Lactating Kilis Goats Applied with Estrus Synchronization During the Breeding Season

Mehmet Dede Tiken, Mustafa Kemal Sarıbay, Gökhan Uyanık   +2 more
openalex   +2 more sources

Expression, Characterization, and Immobilization of a Novel D-Lactate Dehydrogenase from Salinispirillum sp. LH 10-3-1 [PDF]

Jianguo Liu, X Y Jiang, Yaru Zheng, Kaixuan Li, Rui-Xin Zhang, Jingping Xu, Zhe Wang, Yuxuan Zhang, Haoran Yin, Jing Li   +9 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Control of Cardiac Output with Ivabradine or Beta-Blockers for Refractory Hypoxemia under Veno-Venous ECMO for Severe ARDS. [PDF]

Cardiovasc Drugs Ther
Masi P, Tchatat Wangueu L, Bagate F, Plesa A, Folliguet T, Mekontso Dessap A.   +5 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Lung ultrasound and mortality in a cardiogenic shock population: A prospective registry-based analysis. [PDF]

Eur J Heart Fail
Tavazzi G, Colombo CNJ, Pagnesi M, Bertaina M, Montisci A, Frea S, Marini M, Briani M, Patrini L, Rossi F, Bertoldi L, Maj G, Viola G, Sorini Dini C, Valente S, De Ferrari GM, Morici N, Pappalardo F, Sacco A, on behalf of the Altshock Group.   +19 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source