Results 231 to 240 of about 379,267 (388)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Patterns of Disease Progression and Outcomes of Inferior ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock: The Multicenter INSTINCT Registry. [PDF]

J Clin Med
Botti G, Pieri M, Cappannoli L, Munafò AR, Gramegna M, Gamardella M, Camporotondo R, Aurigemma C, Ferlini M, Guida S, Cascone A, Russo F, Lanzillo G, Burzotta F, Montorfano M, Scandroglio AM, Chieffo A.   +16 more
europepmc   +1 more source

Metabolic Effects of Intraruminal Administration of 1,3-Butanediol or Tributyrin in Lactating Goats

, 1989
J.K. Drackley, Y. Zhang, Donna M. Amaral, J.W. Young   +3 more
openalex   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Sex-related differences in systemic inflammatory response and outcomes after cardiac surgery and cardiopulmonary bypass. [PDF]

Interdiscip Cardiovasc Thorac Surg
Squiccimarro E, Lorusso R, Margari V, Labriola C, Whitlock R, Paparella D.   +5 more
europepmc   +1 more source

Comparative Evaluation of Ringer Lactate Infusion of National and Multinational Brand available in Nowshehra, Pakistan

Zawar Hussain, Muhammad Abbas, Saqib Jahan, Abdul Mateen, Ali Khan, Naveed Ahmad, Muhammad Sohail Anwar, Abdul Saboor, Hafiz Sajid Akbar, Rafiullah ., Abdullah ., Wahab Ali, Muhammad Ikram   +12 more
openalex   +2 more sources

Acupuncture on Lactate, Perceived Exertion in Recreational Athletes Submitted to HIIT

, 2020
Carlos Soares Pernambuco, Rodrigo Gomes de Souza Vale, João Rafael Valentim‐Silva, Carlos Alberto de Souza Filho, Vinicius do Espírito Santo de Jesus, Eliane da Silva Borges, Leandra Silva Cardoso, Isabel Cristina Ribeiro Regazzi, Estélio Henrique Martin Dantas   +8 more
openalex   +2 more sources

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

All-Round Talent: Unique Zinc Guanidine Catalyst Performs Efficiently in Synthesis and Chemical Recycling of (Bio)Polyesters. [PDF]

Adv Sci (Weinh)
Becker T, Takeuchi K, Süßmuth C, Boekhoff F, Schäfer MA, Kato S, Hoffmann A, Hayashi T, Herres-Pawlis S.   +8 more
europepmc   +1 more source