Results 241 to 250 of about 318,888 (340)

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Clinical Evaluation of Microneedle Biosensors for Continuous Lactate Monitoring in Critically Ill Patients. [PDF]

ACS Sens
Djassemi O, Chang AY, McGuire WC, Mitchell E, Saha T, Fernandes T, Yang J, Miller M, Wurster C, Morales-Fermin S, McGregor I, Castillo-Valdovinos J, Malhotra A, Wang J.   +13 more
europepmc   +1 more source

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Sex-related differences in systemic inflammatory response and outcomes after cardiac surgery and cardiopulmonary bypass. [PDF]

Interdiscip Cardiovasc Thorac Surg
Squiccimarro E, Lorusso R, Margari V, Labriola C, Whitlock R, Paparella D.   +5 more
europepmc   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

All-Round Talent: Unique Zinc Guanidine Catalyst Performs Efficiently in Synthesis and Chemical Recycling of (Bio)Polyesters. [PDF]

Adv Sci (Weinh)
Becker T, Takeuchi K, Süßmuth C, Boekhoff F, Schäfer MA, Kato S, Hoffmann A, Hayashi T, Herres-Pawlis S.   +8 more
europepmc   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Prenatal ultrasound diagnosis of fetal upper gastrointestinal bleeding in a monochorionic twin pregnancy: a case report. [PDF]

BMC Pregnancy Childbirth
Gavotto A, Gaudaire A, Fuchs F.
europepmc   +1 more source

Toxic Shock Syndrome Due to Streptococcus pyogenes: A Case Series. [PDF]

Cureus
Tavares T, Domingos J, Zaruba V, Nobre C, Sousa M.   +4 more
europepmc   +1 more source

The Effect of Percutaneous Coronary Intervention on Patients with Acute Myocardial Infarction and Cardiogenic Shock Supported by Extracorporeal Membrane Oxygenation. [PDF]

Rev Cardiovasc Med
Wang Y, Fu H, Li J, Xie H, Li C, Du Z, Hao X, Wang H, Wang L, Hou X.   +9 more
europepmc   +1 more source