Results 221 to 230 of about 318,888 (340)

New Diagnostic Score for Sepsis in Adult Horses with Acute Gastrointestinal Disease. [PDF]

Animals (Basel)
Blangy-Letheule A, Montnach J, Perrier J, Lemonnier LC, Denis M, Rozec B, Lauzier B, Leroux AA.   +7 more
europepmc   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Low-normal birthweight in the first pregnancy as a risk factor for small for gestational age in the second pregnancy: A matched case-control study. [PDF]

Pregnancy (Hoboken)
Jeremy B, Richard B, Rozenberg P.
europepmc   +1 more source

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

Advanced Science, EarlyView.
Schematic illustration of the mechanism by which ZIF‐90@PU alleviates osteoporosis via H3K18la‐mediated NFATc1 pathway suppression. ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage.
Jiajia Lu, Yue Xi, Sheng Wang, Ye Chen, Jiajie Yang, Xiaojian Shi   +5 more
wiley   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

Outcomes, prognostic factors, and the role of intracranial pressure monitoring in severe community-acquired bacterial meningitis: a multicenter retrospective cohort study. [PDF]

Lancet Reg Health Eur
Poirier C, Terzi N, Roesch N, Argaud L, Jouin S, Le Pape M, Lavillegrand JR, Hyvernat H, Tymen R, Lafarge P, Bougon D, Bauduin P, Mallet J, Jabot J, Navarro G, Arrivé F, Bernier J, Badet M, Decavele M, Curtiaud A, Bendiab E, Balanca B, Champigneulle B, Hraiech S, Le Guennec L, Fournier E, Canet E, Sonneville R, Dumas G, MAC-ICU Study Group.   +29 more
europepmc   +1 more source

The In Situ Electrochemical−Chemical Cascade Strategy for Pyruvic Acid Synthesis

Advanced Science, EarlyView.
By employing an “unsaturation−oxygen coordination engineering” strategy, the local coordination environment is regulated to achieve efficient electrochemical synthesis of H2O2. Importantly, an electrochemical−chemical coupled cascade strategy is utilized for the efficient preparation of pyruvic acid via lactic acid oxidation. ABSTRACT Hydrogen peroxide
Xueli Mei, Huawei Zhuo, Yu Liu, Lili Wang, Yudai Huang, Hongtao Xie, Yizhao Li   +6 more
wiley   +1 more source

Patterns of Disease Progression and Outcomes of Inferior ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock: The Multicenter INSTINCT Registry. [PDF]

J Clin Med
Botti G, Pieri M, Cappannoli L, Munafò AR, Gramegna M, Gamardella M, Camporotondo R, Aurigemma C, Ferlini M, Guida S, Cascone A, Russo F, Lanzillo G, Burzotta F, Montorfano M, Scandroglio AM, Chieffo A.   +16 more
europepmc   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source