Results 201 to 210 of about 379,267 (388)

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Development of lactate sensors and transfer to printed electronics

, 2016
Gaëtan Scheiblin
openalex   +1 more source

Performance of lactating dairy cows fed sunflower or corn silages and concentrate based on citrus pulp or ground corn

, 2022
Leonardo Andrade Leite, R.B. Reis, Patrícia Guimarães Pimentel, H.M. Saturnino, S.G. Coelho, Guilherme Rocha Moreira   +5 more
openalex   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

<i>Ex-Vivo</i> Heart Perfusion Machines in DCD Heart Transplantation Model: The State of Art. [PDF]

Transpl Int
Tessari C, Lucertini G, Addonizio M, Geatti V, Bacich D, Pradegan N, Fabozzo A, Bianco R, Toscano G, Tarzia V, Gerosa G.   +10 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Risk factors for electrographic seizures in infants after cardiac surgery and their association with outcomes: a retrospective cohort study. [PDF]

Sci Rep
Ranucci M, Mastrangelo M, Sperandeo F, Lodovici M, Lamastra R, Aloisio T, Anguissola M, Barbaria A, Capizzi MR, Giamberti A, Isgrò G.   +10 more
europepmc   +1 more source

Use of plasma lactate level to predict 28-day mortality in non-elderly and elderly sepsis patients based on the MIMIC-III database [PDF]

, 2019
Yihua Dong, Xiaoyang Miao, Yufeng Hu, Yueyue Huang, Jie Chen, Yingru Lu, Jingye Pan   +6 more
openalex   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Sperm motility and lactate production at different sperm concentrations

, 2013
Jérôme Ponthier, Pascal De Tullio, D. Blommaert, Sonia Parrilla Hernández, Stéfan Deleuze   +4 more
openalex   +2 more sources