Results 71 to 80 of about 1,126 (255)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Preparation of o-palmitoyl alkyl lactates through lipase catalysis.

, 2002
Preparation of o-palmitoyl alkyl lactates with methyl,ethyl ,prop yl,isopropy l and butyl lactates were attempted in a complex esterification reaction using lipases as catalysts.
Kiran, K. R., Divakar, S.
core  

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Identifying high-risk undifferentiated emergency department patients with hyperlactatemia: Predictors of 30-day in-hospital mortality

Turkish Journal of Emergency Medicine
BACKGROUND: Hyperlactatemia has been recognized as a significant prognostic indicator in critically ill patients. Nonetheless, there remains a gap in understanding the specific risk factors contributing to increased mortality among undifferentiated ...
Ayşen Aydın Kaçar, Ersin Aksay, Başak Bayram, Emre Kıran, Bahar Elif Güldalı   +4 more
doaj   +1 more source

Chemocatalytic Production of Lactates from Biomass-Derived Sugars

International Journal of Chemical Engineering, 2018
In recent decades, a great deal of attention has been paid to the exploration of alternative and sustainable resources to produce biofuels and valuable chemicals, with aims of reducing the reliance on depleting confined fossil resources and alleviating ...
Heng Zhang, Yulin Hu, Liying Qi, Jian He, Hu Li, Song Yang   +5 more
doaj   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Constructing Novel Biobased Phosphorus-Containing Oligomeric Lactates toward Synchronously Enhancing the Toughness and Fire Safety of Poly(lactic acid)

Simultaneously improving the flame retardancy and toughness of polylactic acid (PLA) remains a huge challenge. In this work, we report a simple method for synthesizing PLA blended with biobased phosphorus-containing oligomeric lactates.
Boyou Hou (12245712), Yun Zhang (131894), Zhendong Chen (482666), Bingjian Li (14379324), Qianqian Cui (3599906), Xueying Shan (1835257), Bin Xu (10691), Jinchun Li (2626354)   +7 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Variations in capillary and serum lactates levels based on different etiologies of septic patients in the emergency department

Frontiers in Medicine
IntroductionSepsis is a life-threating and time-depending condition. This study examined the association between sepsis etiology and variations in capillary and serum lactate levels, neutrophil-to-lymphocyte ratio, and diastolic shock index in emergency ...
Matteo Guarino, Matteo Guarino, Benedetta Perna, Giacomo Maroncelli, Paolo Baldin, Chiara Donati, Francesco Luppi, Alice Eleonora Cesaro, Chiara Pesci, Anna Costanzini, Martina Maritati, Paolo Clavenzani, Carlo Contini, Roberto De Giorgio, Michele Domenico Spampinato, Michele Domenico Spampinato   +15 more
doaj   +1 more source