Results 51 to 60 of about 318,888 (340)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The effects of short term β-alanine supplementation on blood lactate concentration of young male athletes [PDF]

فصلنامه ابن سینا, 2014
Background: Dietary Supplements consumption among young athlete widely prevails regardless of well documented scientific proof of their effectiveness in improving exercise performance.
M Eslamdust, B Bazgir, E Kowsari, AR Rahimi, A Sarshin, S Naghibie   +5 more
doaj  

Metabolism-Guided Bowel Resection: Potential Role and Accuracy of Instant Capillary Lactates to Identify the Optimal Resection Site

, 2015
Background. Strip-based handheld devices can measure lactatemia on capillary blood obtained by needle puncturing. We aimed to assess the kinetic of bowel capillary lactates, metabolomics profiling, and mitochondria respiratory rate in a prolonged model ...
Marescaux, J, Namer, I, Agnus, V, Diana, M, Lindner, Veronique, Charles, Anne, Geny, Bernard, Noll, Eric, Moussallieh, F, Diemunsch, Pierre   +9 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Correlation between Persistent Serum Lactate Elevation and Brain Magnetic Resonance Imaging Abnormalities in Children with Status Epilepticus [PDF]

Annals of Child Neurology
Purpose This study was conducted to evaluate the correlation between persistent serum lactate elevation and brain magnetic resonance imaging (MRI) in children with status epilepticus (SE).
Prastiya Indra Gunawan, Riza Noviandi, Sunny Mariana Samosir   +2 more
doaj   +1 more source

Normal saline versus balanced crystalloids in patients with prerenal acute kidney injury and pre-existing chronic kidney disease

Romanian Journal of Internal Medicine, 2023
Normal saline (N/S) and Ringer’s-Lactate (L/R), are administered in everyday clinical practice. Despite that, N/S increases the risk of sodium overload and hyperchloremic metabolic acidosis.
Papasotiriou Marios, Mpratsiakou Adamantia, Georgopoulou Georgia, Ntrinias Theodoros, Balta Lamprini, Pavlakou Paraskevi, Goumenos Dimitrios S., Papachristou Evangelos   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Enantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes

Nature Communications, 2023
Organosilanes possessing an enantioenriched stereogenic silicon center are important in many branches of chemistry, yet they remain challenging to synthesize in a practical and scalable way. Here we report a dynamic kinetic silyletherification process of
Tianbao Hu, Chen Zhao, Yan Zhang, Yuzhong Kuang, Lu Gao, Wanshu Wang, Zhishan Su, Zhenlei Song   +7 more
doaj   +1 more source

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

Journal of Biophotonics, 2018
Instant measurement of elevated biomarkers such as lactic acid offers the most promising approaches for early treatment and prevention of many critical diseases including cardiac arrest, stroke, septic shock, trauma, liver dysfunction, as well as for ...
T. Kakkar, Nikita Thomas, E. Kumi-Barimah, G. Jose, S. Saha   +4 more
semanticscholar   +1 more source

Surface Tensions of Alkyl Lactates with n‑Alkanols or Branched Alkanols

, 2022
The surface behavior of 18 binary mixtures at T = 298.15 K and at atmospheric pressure (p = 0.1 MPa) was measured with a drop volume tensiometer. These mixtures are formed by alkyl lactates (methyl lactate and ethyl lactate) and alcohols (n-alkanols from
Saoussen Wacharine (14307937), Héctor Artigas, Héctor Artigas (2319181), Carlos Lafuente (1278918), Kaïs Antar, Carlos Lafuente, Carmen Almodovar (14307934), Saoussen Wacharine, Kaïs Antar (14307940), Carmen Almodovar   +9 more
core   +1 more source