Results 61 to 70 of about 2,048,354 (300)

Investigating the effect of temporal, geographic, and management factors on US Holstein lactation curve parameters

Journal of Dairy Science, 2022
: We fit the Wood's lactation model to an extensive database of test-day milk production records of US Holstein cows to obtain lactation-specific parameter estimates and investigated the effects of temporal, spatial, and management factors on lactation ...
M. Li, G.J.M. Rosa, K.F. Reed, V.E. Cabrera   +3 more
doaj   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

The effect of calf gender on milk lactation traits and lactation gain of Holstein and Simmental cows

Mljekarstvo, 2022
Considering the challenging market conditions for dairy farms, calf gender management should be one of the tools used to increase profitability. The objective of this paper was to examine the effect of calf gender on lactation milk traits in Holstein and
Mato Čačić, Zoran Grgić, Marija Špehar, Ante Ivanković   +3 more
doaj  

A covariance function for feed intake, live weight and milk yield estimated using a random regression model [PDF]

, 1999
To enable investigation of genetic variation during early lactation in heifers, multitrait covariance functions were used to describe genetic covariances among feed intake, live weight, and milk yield during the first 15 wk of lactation (n = 628). Random
Veerkamp, R. F., Thompson, R.
core   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Genetic studies on various production and reproduction traits of Sahiwal and crossbred cattle (HFxJerseyxSahiwal) of an organised farm

Veterinary World, 2010
The present investigation was undertaken on data of 30 Sahiwal cattle and 30 crossbred cattle (HF × Jersey × Sahiwal) from Instructional Dairy Farm (IDF), G.B. Pant University of Agriculture & Technology, Pantnagar, Uttarakhand.
Anjan Dandapat, Dipak Banerjee, Dibyendu Chakraborty   +2 more
doaj  

Multi-trait covariance functions to estimate genetic correlations between milk yield, dry matter intake and live weight during lactation

, 1999
Energy balance is a function of dry-matter intake (DMI), live weight and milk yield over a certain time period. To investigate potential strategies to use genetic selection for the improvement of the negative energy balance, genetic co-variances were ...
Veerkamp, R. F., Thompson, R., Thompson, Robin   +2 more
core   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Effects of Stage of Lactation and Pregnancy and Their Interactions on Milk Yield and Constituents

Journal of Dairy Science, 1990
Effects of stage of lactation and pregnancy and their interactions on 17 milk yield and constituent traits of Holsteins and Jerseys were studied. Data were 11,120 Jersey and 11,092 Holstein daily milk samples. After adjustment for all other known and systematic genetic and environmental effects, stage of lactation influenced all traits and accounted ...
A K, Sharma, C J, Wilcox, F G, Martin, W W, Thatcher   +3 more
openaire   +2 more sources

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source