Results 41 to 50 of about 220,021 (254)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Research progress on the production mechanism and control measures of two chiral lactic acid in Baijiu brewing process [PDF]

Zhongguo niangzao
In Baijiu brewing process with open fermentation, lactic acid bacteria were introduced into fermented grains to produce L-lactic acid and D-lactic acid.
YANG Rong, HUA Jin, ZHOU Yabin
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Effect of Carbon Source on Cell Viability during Culture of Bifidobacterium longum subsp. infantis

Shipin gongye ke-ji
Bifidobacterium exhibits distinct physiological subpopulations during cultivation, which influences its metabolic activity and enhancement of the number of viable bacteria. This study focused on Bifidobacterium longum subsp.
Xiaoyuan ZHANG, Kailong LIU, Zhan YANG, Min LI, Yi ZHANG, Guangzhong LIU, Heping ZHANG, Wenyi ZHANG, Guoqiang YAO   +8 more
doaj   +1 more source

Decoupling Light Absorption From Photocatalytic Reactivity in TiO2 via Defect and Interfacial Engineering

Advanced Functional Materials, EarlyView.
A hybrid photoprotective material integrates N‐doped TiO2 with a metal‐phenolic network (MPN) to achieve broad‐spectrum attenuation and robust reactive oxygen species (ROS) suppression. Nitrogen doping extends attenuation into the UVA/high energy visible light (HEV) regions and facilitates fast charge recombination to inhibit ROS formation.
Saehan Choi, Heewon Kim, Dongwoo An, KwangHo Lee, Minkyoung Kim, Yunhwa Hong, Kwang Heo, Jongwon Shim, EunAe Cho, Yoonsung Nam   +9 more
wiley   +1 more source

Phenotypic characterization and genomic analysis of Limosilactobacillus fermentum phage

Current Research in Food Science
Limosilactobacillus (L.) fermentum is widely utilized for its beneficial properties, but lysogenic phages can integrate into its genome and can be induced to enter the lysis cycle under certain conditions, thus accomplishing lysis of host cells ...
Can Zhang, Xingyu Quan, Weiqi Lian, Runze Liu, Qiannan Wen, Xia Chen   +5 more
doaj   +1 more source

Lactic Acid: A Novel Signaling Molecule in Early Pregnancy?

Frontiers in Immunology, 2020
Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta, trophoblasts and decidual immune cells can also produce a large amount ...
Li-Na Ma, Xiao-Bo Huang, Kahindo P. Muyayalo, Gil Mor, Gil Mor, Ai-Hua Liao   +5 more
doaj   +1 more source

Three‐Dimensional Biomimetic Aerogel Conduits with Electro‐Ionic‐Immune Coupling Reverse the Pathological Cascade of Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic aerogel conduit was engineered from a nanofiber of gelatin/poly(l‐lactic acid) doped with polypyrrole nanoparticles, integrated with tannic acid and Mg2+. This “electro‐ionic‐immune” strategy mimicked spinal cord properties, reduced calcium overload, inflammation, oxidative damage, promoted neural stem cell differentiation, suppressed ...
Qingxiang Liu, Xin Yu, Jingtong Li, Chunyang Zheng, Yukang Zhang, Mingyu Jia, Tan Tian, Weiwei Zheng, Pinghui Zhou, Yingji Mao   +9 more
wiley   +1 more source

Effect of pH Control in Fermentation System on Division Cycle of Bifidobacterium breve

Shipin gongye ke-ji
pH control was a key regulatory strategy in the high-density cultivation of Bifidobacteria. However, research into the mechanisms by which pH regulates cell division and proliferation remains limited.
Min LI, Zhan YANG, Kailong LIU, Xiaoyuan ZHANG, Yi ZHANG, Wenyi ZHANG, Heping ZHANG, Guoqiang YAO   +7 more
doaj   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source