Results 51 to 60 of about 297,703 (307)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Transcriptional analysis of the molecular mechanism underlying the response of Lactiplantibacillus plantarum to lactic acid stress conditions

Heliyon, 2023
Lactic acid bacteria (LAB) present various benefits to humans; they play key roles in the fermentation of food and as probiotics. Acidic conditions are common to both LAB in the intestinal tract as well as fermented foods.
Ha-Young Jang, Min Ji Kim, Minseo Bae, In Min Hwang, Jong-Hee Lee   +4 more
doaj   +1 more source

Deep subcutaneous application of poly-L-lactic acid as a filler for facial lipoatrophy in HIV-infected patients [PDF]

, 2005
Introduction: Facial lipoatrophy is a crucial problem of HIV-infected patients undergoing highly active antiretroviral therapy (HAART). Poly-L-lactic acid (PLA), provided as New-Fill(R)/Sculptra(TM), is known as one possible treatment option. In 2004 PLA
Borelli, Claudia, Korting, Hans Christian, Weisenseel, P., Thoma-Greber, E., Konz, B., Kunte, C.   +5 more
core   +1 more source

Design and synthesis of different types of poly(lactic acid)/polylactide copolymers

, 2022
High molar mass poly(lactic acid) (PLA) is obtained by either the polycondensation of lactic acid or ring-opening polymerization (ROP) of the cyclic dimer 2,6-dimethyl-1,4-dioxane-2,5-dione, commonly referred to as dilactide or lactide (LA). This chapter
Lochab, Bimlesh,, Varma, Indra Kumari,, Kumar, Kamlesh,, Albertsson, Ann-Christine,, Finne Wistrand, Anna,, Sahu, Sangeeta,   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hyperammonemia reduces the populations of beneficial lactobacilli and bifidobacteria, disrupting the metabolic balance of the gut microbiome in rats

Frontiers in Microbiology
IntroductionThe gut microbiome (GM) plays a critical role in metabolic and neurological health and is implicated in hepatic encephalopathy (HE). Chronic hyperammonemia (HA), a major contributor to cognitive and motor impairment in HE, may influence GM ...
Lola Giner-Pérez, Vicente Felipo, Paula Izquierdo-Altarejos, Paula Izquierdo-Altarejos, Marta Llansola, Gaspar Pérez Martínez   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Benefits of Regular Intake of Glucolacto-Oligosaccharides on Gut Health in Adults with Low Defecation Frequency: A Randomized, Double-Blind, Placebo-Controlled Study

Microorganisms
The significance of less abundant genera within the gut microbiota, such as Parabacteroides, remains largely unexplored. Despite its low levels, Parabacteroides is highly conserved and potentially beneficial across populations.
Yuichi Yoshizawa, Junya Ishida, Atsushi Shimonaka, Satoshi Hanamura, Akika Nagira, Mami Minakata, Akiko Koizumi, Aoi Fujieda, Hiroki Negishi, Shigenori Kanemura, Seiya Makino, Kenichi Hojo   +11 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Study on improving the properties of rice flour and rice vermicelli quality by heat treatment with lactic acid solutions

Liang you shipin ke-ji, 2020
The paper mainly studies the effect of heat treatment with lactic acid on properties of rice flour and quality of dried rice vermicelli and wet rice vermicelli.Indica rice flour by water milling was selected as raw material and treated with different ...
LIU Hui-hui, LIAO Lu-yan
doaj   +1 more source