Results 111 to 120 of about 217,585 (392)

Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

Journal of the American Chemical Society, 2014
Flavaglines are a class of natural products with potent insecticidal and anticancer activities. β-Lactones are a privileged structural motif found in both therapeutic agents and chemical probes. Herein, we report the synthesis, unexpected light-driven di-
Neil J. Lajkiewicz, A. Cognetta, M. Niphakis, B. Cravatt, J. Porco   +4 more
semanticscholar   +1 more source

Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer [PDF]

, 2015
Chiral, dimeric natural products containing complex structures and interesting biological properties have inspired chemists and biologists for decades.
A Zask, Anne C. Meister, B Franck, BB Liau, BH Lipshutz, CA Broka, CE Müller, CF Nising, DA Evans, F Guo, G Bringmann, G Bringmann, G Xu, GA Molander, GP Moss, H Kikuchi, H Kikuchi, J Clayden, JM Wilson, John A. Porco, K-S Masters, KC Nicolaou, LC Konkol, LF Tietze, LF Tietze, LF Tietze, M Stewart, MC Kozlowski, NC Bruno, NZ Burns, PS Steyn, R Martin, Richard P. Johnson, Robert J. Capon, RS Coleman, S Huang, S Little, S Masamune, Sarah L. Skraba-Joiner, SR LaPlante, T Gensch, T Hamada, T Qin, T Qin, T Wezeman, TE Barder, Tian Qin, VB Birman, W Tang, X Shen, Y Zhou, Y Zhou, YS Park, Zeinab G. Khalil   +53 more
core   +2 more sources

Tratamiento de miasis oral con Ivermectina notificación de tres casos causados por Cochliomyia Hominivorax (COQUEREL)

Revista Facultad de Odontología Universidad de Antioquia, 1998
Myiasis is the infestation of the body tissues of man and animals by the larvae of Diptera (Two winged flies). It has been observed in differents areas of humans, but is uncommon in the oral cavity.
Francisco Levi Duque-Serna , Rafael Valderrama-Hernández , Jorge Alonso González-Robledo   +2 more
doaj  

Crystal structure of 5-O-benzoyl-2,3-O-isopropylidene-d-ribono-1,4-lactone

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C15H16O6, obtained from the acylation reaction between 2,3-O-isopropylidene-d-ribono-1,4-lactone and benzoyl chloride, the known absolute configuration for the lactone moiety of the ester substituent has been confirmed.
Adailton J. Bortoluzzi, Gustavo P. Silveira, Marcus M. Sá   +2 more
doaj   +1 more source

Secalonic acid A from Pseudoparmelia sphaerospora (Nyl.) Hale and P. hypomilta (Fée) Hale (Parmeliaceae) [PDF]

, 1995
Secalonic acid A, a yellow pigment from fungal metabolism, was isolated from the lichens Pseudoparmelia sphaerospora and P. hypomilta. From P. sphaerospora was also isolated the depsidone hypostictic acid.
Devincenzi, Izilda A. A., Filho, Lauro Xavier, Honda, Neli K.   +2 more
core   +1 more source

lactones

, 2014
Citation: 'lactones' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.L03439 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria [PDF]

, 2017
Host immune and physical barriers protect against pathogens but also impede the establishment of essential symbiotic partnerships. To reveal mechanisms by which beneficial organisms adapt to circumvent host defenses, we experimentally evolved ...
Cooper, Vaughn S., Coyle, Matthew, Donner, Rachel A., Foxall, Randi L., Pankey, Molly Sabrina, Perry, Lauren A., Schuster, Brian M., Ster, Ian M., Whistler, Cheryl A.   +8 more
core   +3 more sources

Conversion of the Mycotoxin Patulin to the Less Toxic Desoxypatulinic Acid by the Biocontrol Yeast Rhodosporidium kratochvilovae Strain LS11 [PDF]

, 2011
Se describe en este artículo el descubrimiento de la degradación de la micotoxina patulina por una levaduraThe infection of stored apples by the fungus Penicillium expansum causes the contamination of fruits and fruit-derived products with the mycotoxin
Alberto Ritieni, Anatoly P. Sobolev, Bourdiol D., Castoria R., Castoria R., Castoria R., Castoria R., Castoria R., Castoria R., Cole R. J., Cristina Pinedo-Rivilla, Dario V. De Felice, de Felice D. V., Ferrer E., Fliege R., Fliege R., Francesca Maffei, Harwig J., Ippolito A., Janisiewicz W. J., Karlovsky P., Lilly V. G., Lima G., Luisa Mannina, MacDonald S., Mahfoud R., Mannina L., Moake M. M., Moss M. O., Patterson M. K., Pfeiffer E., Raffaello Castoria, Rosa Durán-Patrón, Rosalia Ferracane, Sandra A. I. Wright, Scott P. M., Si-min Z., Stinson E. E., Suzuki T., Uliasz F., Wallen L. L.   +40 more
core   +2 more sources

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT: Pharmacometrics & Systems Pharmacology, 2019
The drug–drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs).
Bridget L. Morse, Jeffrey J. Alberts, Maria M. Posada, Jessica Rehmel, Anil Kolur, Lai San Tham, Corina Loghin, Kathleen M. Hillgren, Stephen D. Hall, Gemma L. Dickinson   +9 more
doaj   +1 more source

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [PDF]

, 2013
Key Points First report demonstrating in vivo elimination of multiple LIC populations from childhood ALL cases using animal models. In vivo models of leukemia are essential for drug evaluation studies.
Blair, Allison, Cox, Charlotte V, Diamanti, Paraskevi, Moppett, John P   +3 more
core   +2 more sources