Results 131 to 140 of about 140,146 (333)
Advanced NanoBiomed Research, EarlyView.Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo +2 more
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Angewandte Chemie, EarlyView.This work demonstrates an unconventional mechanism in Lewis basic selenium‐catalyzed electrophilic halogenation, where in situ oxidation of selenourea by the halogen source generates hypervalent Se‐imidazolium species. These intermediates function as hydrogen‐bond catalysts to activate N‐haloamide reagents, enabling efficient and mild halogenation of ...
Jingxian Huang +6 more
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Ueber Phtalylderivate. I. Umwandlung der Ketonsäuren in Lactone [PDF]
, 1884 W. Roser
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Arkivoc, 2003 A robust and versatile kinetic alkylation-ozonolysis procedure, previously used for the synthesis of 2-alkyl-2-cyclopenten-1-ones and racemic γ-substituted-γ-lactones, has now been applied to the synthesis of chiral γ-substituted-γ-lactones and δ-substituted-δ-lactones. In addition to the synthesis of lactones with simple alkyl substituents, the method
Niall W. A. Geraghty, Declan P. Costello
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The odour of white bread [PDF]
, 1973 Volatile constituents of white bread were investigated. Different methods were used for isolating and concentrating components to avoid artefacts as far as possible. Especially good was enlarged vapour analysis.
Mulders, E.J.
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Die Chemie und Biologie der Tetrodotoxin Naturstofffamilie
Angewandte Chemie, EarlyView.Tetrodotoxin ist vor allem als das Gift des Kugelfisches bekannt, einer Delikatesse in der japanischen Küche. Seine Toxizität beruht auf der selektiven Blockade von NaV Kanälen, wie am Beispiel der NaV1.7 Pore dargestellt, wobei das DEKA Motiv hervorgehoben ist, das für die Durchlässigkeit von Natriumionen verantwortlich ist.
Benedikt Nißl +6 more
wiley +1 more source
Iron‐Catalyzed Carbonylation Reactions with Carbon Monoxide
Angewandte Chemie, EarlyView.Recent developments in iron‐catalyzed carbonylative transformations using CO as a C₁ feedstock are summarized in this minireview. Reaction mechanisms of selected reactions and the potential for further advancements in this field are also discussed. Abstract The utilization of carbon monoxide (CO) as an inexpensive and indispensable C1 feedstock for the
Kangkang Sun +3 more
wiley +2 more sources
Synthesis of (+)-Marmelo Lacton A and (+)-Marmelo Lactone B [PDF]
Agricultural and Biological Chemistry, 1983 Hiroshi Meguro +2 more
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Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis
Angewandte Chemie, EarlyView.A triple C─C cascade approach to the synthesis of heteroaryl cyclopropanes is described. The reaction is metal‐free, uses simple starting materials, and presents a new retrosynthetic approach for heteroaryl cyclopropane synthesis. A change of substituent creates a new route to sultines, under‐explored motifs in medicinal chemistry. Abstract We describe
Thomas Sephton +2 more
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(6R,7R)-3-Hydroxymethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylic acid lactone
Acta Crystallographica Section E, 2011 In the title compound {systematic name: N-[(4R,5R)-3,11-dioxo-10-oxa-6-thia-2-azatricyclo[6.3.0.02,5]undec-1(8)-en-4-yl]-2-phenylacetamide}, C16H14N2O4S, the four- and five-membered rings adopt planar conformations (with r.m.s. deviations of 0.0349 and 0.
Xiao-Liang Zhou +3 more
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