Results 221 to 230 of about 217,585 (392)

Rapid Structural Analysis of Natural Products Using MicroED

Small, EarlyView.
The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin, Orel Paz, Johan Unge, Tamir Gonen   +3 more
wiley   +1 more source

Turning Mushy Lipids into Fruity Notes: Unlocking Lactone Biosynthesis Potential in Fat Industry Lipid Waste. [PDF]

Foods
Małajowicz J, Wierzchowska K, Jasińska K, Fabiszewska A.   +3 more
europepmc   +1 more source

Stereochemistry in the hydrogenation of steroidal (22R)- and (22S)-.DELTA.24-26,22-lactones.

, 1986
Hiroshi Iwadate, Keiji Gamoh, Yoshinori Fujimoto, Nobuo Ikekawa   +3 more
openalex   +2 more sources

Lewis Acid‐Triggered Spatiotemporally Controllable Ring Opening in a Classic Rhodamine Featuring Φ = 95% Emission

Small Science, EarlyView.
This work reports a breakthrough in rhodamine activation via an elegant Lewis acid coordination strategy. It induces ring opening in spirolactone rhodamine TMR, generating exceptional fluorescence (quantum yields up to 95%) without destructive modifications or structural modification. The method preserves full photocontrol, reversibility, and real‐time
Quanchun Sun, Liancheng He, Tao Wang, Haiyan Cui, Xinping Wang   +4 more
wiley   +1 more source

A Concise and Divergent Approach to the Naturally Occurring Tetracyclic Clavine Alkaloids (+)-Lysergol, (+)-Lysergine, and (+)-Isolysergine. [PDF]

J Org Chem
Regni A, Bartoccini F, Piersanti G.
europepmc   +1 more source

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, EarlyView.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source

Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation. [PDF]

J Clin Invest
Weninger G, Dridi H, Reiken S, Yuan Q, Zhao N, Groom L, Leigh J, Liu Y, Tchagou C, Kang J, Chang A, Luna-Figueroa E, Miotto MC, Wronska A, Dirksen RT, Marks AR.   +15 more
europepmc   +1 more source

Organic Transistor‐Based Neuromorphic Electronics and Their Recent Applications

Small Methods, EarlyView.
This review highlights recent progress in organic neuromorphic electronics, showing how organic semiconductors enable synaptic and neuronal functions with low power, mechanical flexibility, and biocompatibility. By bridging materials, devices, and systems, organic platforms are accelerating brain‐inspired computing toward applications in artificial ...
Ziru Wang, Feng Yan
wiley   +1 more source

Effects of Ginkgo diterpene lactone gluconate injection combined with vascular recanalization on patients with large-vessel occlusive cerebral infarction: A clinical observation study. [PDF]

Medicine (Baltimore)
Feng Z, Li M, Li Z, Xiang L, Xu J, Wang J.   +5 more
europepmc   +1 more source

Benzochromanone and Benzochromene Natural Products: Synthetic Strategies and Total Syntheses

The Chemical Record, EarlyView.
This work outlines synthetic strategies for natural products with benzochromanone and benzochromene cores. Key achievements include total syntheses of xanthones, blennolide C, gonytolide C, and teretifolione B. Spirochromanone intermediates, benzyne–furan Diels–Alder reactions, and enzymatic resolution enabled efficient and enantioselective access to ...
Takuya Kumamoto
wiley   +1 more source