Results 1 to 10 of about 25,988 (242)

Novel Halolactones Derived from Vanillin: Design, Synthesis, Structural Characterization, and Evaluation of Antiproliferative and Hemolytic Activities [PDF]

Molecules
A series of novel γ-halo-δ-lactones and δ-halo-γ-lactones bearing a phenolic ring at the β-position were synthesized from vanillin. The divergent seven-step synthetic route commenced with the benzyl protection of the hydroxy group of the starting ...
Anna Dunal, Witold Gładkowski, Ewa Dejnaka, Joanna Sulecka-Zadka, Aleksandra Pawlak, Aleksandra Włoch, Hanna Pruchnik, Gabriela Maciejewska   +7 more
doaj   +2 more sources

Stereoselective synthesis of whisky lactone isomers catalyzed by bacteria in the genus Rhodococcus

Frontiers in Microbiology, 2023
Whisky lactone is a naturally occurring fragrance compound in oak wood and is widely used as a sensory additive in food products. However, safe and efficient methods for the production of its individual enantiomers for applications in the food industry ...
Dawid Hernik, Francesco Gatti, Elisabetta Brenna, Ewa Szczepańska, Teresa Olejniczak, Filip Boratyński   +5 more
doaj   +1 more source

A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease

Antioxidants, 2022
Paraoxonases (PONs) are a family of hydrolytic enzymes consisting of three members, PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological substrates of these enzymes is necessary for the elucidation of their biological roles ...
Chrysan J. Mohammed, Sabitri Lamichhane, Jacob A. Connolly, Sophia M. Soehnlen, Fatimah K. Khalaf, Deepak Malhotra, Steven T. Haller, Dragan Isailovic, David J. Kennedy   +8 more
doaj   +1 more source

Soil and Vegetation Drive Sesquiterpene Lactone Content and Profile in Arnica montana L. Flower Heads From Apuseni-Mountains, Romania

Frontiers in Plant Science, 2022
Arnica montana L. (AM, Asteraceae) is a perennial, herbaceous vascular plant species of commercial importance. The flower heads’ pharmacological properties are attributed mainly to sesquiterpene lactones (SLs), with phenolic acids and flavonoids also ...
Anja Greinwald, Anja Greinwald, Martin Hartmann, Jörg Heilmann, Michael Heinrich, Rainer Luick, Albert Reif   +6 more
doaj   +1 more source

Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones—Comparison of Their Anti-Tumor Activity In Vitro

Molecules, 2021
Background: The study investigated four flavanone-derived γ-oxa-ε-lactones: a parent unsubstituted compound and its three derivatives with the methoxy group in positions 2′, 4′ and 8. Our objective was to find out if the introduction of the methoxy group
Aleksandra Pawlak, Marta Henklewska, Beatriz Hernández-Suárez, Monika Siepka, Witold Gładkowski, Czesław Wawrzeńczyk, Karolina Motykiewicz-Pers, Bożena Obmińska-Mrukowicz   +7 more
doaj   +1 more source

Microbial Reduction of Ketopantoyl Lactone to Pantoyl Lactone [PDF]

Applied Microbiology, 1974
The results of a microbial survey study have shown that the ability to reduce added ketopantoic acid (or ketopantoyl lactone) and accumulate pantoic acid (or pantoyl lactone) in the growth medium is widespread among diverse fungi. The reductions generally proceeded with less than full stereoselectivity.
R P, Lanzilotta, D G, Bradley, K M, McDonald   +2 more
openaire   +2 more sources

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

Biomolecules, 2021
Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto ...
Ashwani Arya, Rubal Chahal, Rekha Rao, Md. Habibur Rahman, Deepak Kaushik, Muhammad Furqan Akhtar, Ammara Saleem, Shaden M. A. Khalifa, Hesham R. El-Seedi, Mohamed Kamel, Ghadeer M. Albadrani, Mohamed M. Abdel-Daim, Vineet Mittal   +12 more
doaj   +1 more source

Synthesis of Spiroisoxazolines by 1,3-Dipolar Cycloaddition

Molecules, 1997
The cycloaddition of the chiral nitrile oxide 1 to 1-R-substituted 3,3-methylene-5,5-dimethyl-2-pyrrolidinones 2 (where R is H, n-butyl-, 1,1-dimethylethoxycarbonyl-, 1-methylethenyl- and acetyl-) proceeds regioselectively under the formation of ...
Peter Ertl, Vladimír Ondrus, Lubor Fisera, Peter Micuch   +3 more
doaj   +1 more source

Lactones with Methylcyclohexane Systems Obtained by Chemical and Microbiological Methods and Their Antimicrobial Activity

Molecules, 2015
Eight new lactones (δ-chloro-, δ-bromo- and δ-iodo-γ-lactones), each with a methylcyclohexane ring, were obtained by chemical means from (4-methylcyclohex-2-en-1-yl) acetic acid or (6-methylcyclohex-2-en-1-yl) acetic acid.
Małgorzata Grabarczyk, Katarzyna Wińska, Wanda Mączka, Anna K. Żołnierczyk, Barbara Żarowska, Mirosław Anioł   +5 more
doaj   +1 more source

Biotransformation of Bicyclic Halolactones with a Methyl Group in the Cyclohexane Ring into Hydroxylactones and Their Biological Activity

Molecules, 2016
The aim of this study was the chemical synthesis of a series of halo- and unsaturated lactones, as well as their microbial transformation products. Finally some of their biological activities were assessed. Three bicyclic halolactones with a methyl group
Katarzyna Wińska, Małgorzata Grabarczyk, Wanda Mączka, Barbara Żarowska, Gabriela Maciejewska, Katarzyna Dancewicz, Beata Gabryś, Antoni Szumny, Mirosław Anioł   +8 more
doaj   +1 more source