Results 1 to 10 of about 98,587 (340)

Novel Halolactones Derived from Vanillin: Design, Synthesis, Structural Characterization, and Evaluation of Antiproliferative and Hemolytic Activities [PDF]

open access: yesMolecules
A series of novel γ-halo-δ-lactones and δ-halo-γ-lactones bearing a phenolic ring at the β-position were synthesized from vanillin. The divergent seven-step synthetic route commenced with the benzyl protection of the hydroxy group of the starting ...
Anna Dunal   +7 more
doaj   +2 more sources

Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity [PDF]

open access: goldMolecules, 2009
Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis.
Fernando Echeverri   +4 more
doaj   +2 more sources

Soil and Vegetation Drive Sesquiterpene Lactone Content and Profile in Arnica montana L. Flower Heads From Apuseni-Mountains, Romania

open access: yesFrontiers in Plant Science, 2022
Arnica montana L. (AM, Asteraceae) is a perennial, herbaceous vascular plant species of commercial importance. The flower heads’ pharmacological properties are attributed mainly to sesquiterpene lactones (SLs), with phenolic acids and flavonoids also ...
Anja Greinwald   +6 more
doaj   +1 more source

Stereoselective synthesis of whisky lactone isomers catalyzed by bacteria in the genus Rhodococcus

open access: yesFrontiers in Microbiology, 2023
Whisky lactone is a naturally occurring fragrance compound in oak wood and is widely used as a sensory additive in food products. However, safe and efficient methods for the production of its individual enantiomers for applications in the food industry ...
Dawid Hernik   +5 more
doaj   +1 more source

A PON for All Seasons: Comparing Paraoxonase Enzyme Substrates, Activity and Action including the Role of PON3 in Health and Disease

open access: yesAntioxidants, 2022
Paraoxonases (PONs) are a family of hydrolytic enzymes consisting of three members, PON1, PON2, and PON3, located on human chromosome 7. Identifying the physiological substrates of these enzymes is necessary for the elucidation of their biological roles ...
Chrysan J. Mohammed   +8 more
doaj   +1 more source

Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones—Comparison of Their Anti-Tumor Activity In Vitro

open access: yesMolecules, 2021
Background: The study investigated four flavanone-derived γ-oxa-ε-lactones: a parent unsubstituted compound and its three derivatives with the methoxy group in positions 2′, 4′ and 8. Our objective was to find out if the introduction of the methoxy group
Aleksandra Pawlak   +7 more
doaj   +1 more source

Synthesis of Spiroisoxazolines by 1,3-Dipolar Cycloaddition

open access: yesMolecules, 1997
The cycloaddition of the chiral nitrile oxide 1 to 1-R-substituted 3,3-methylene-5,5-dimethyl-2-pyrrolidinones 2 (where R is H, n-butyl-, 1,1-dimethylethoxycarbonyl-, 1-methylethenyl- and acetyl-) proceeds regioselectively under the formation of ...
Peter Ertl   +3 more
doaj   +1 more source

Microbial Reduction of Ketopantoyl Lactone to Pantoyl Lactone [PDF]

open access: yesApplied Microbiology, 1974
The results of a microbial survey study have shown that the ability to reduce added ketopantoic acid (or ketopantoyl lactone) and accumulate pantoic acid (or pantoyl lactone) in the growth medium is widespread among diverse fungi. The reductions generally proceeded with less than full stereoselectivity.
R P, Lanzilotta   +2 more
openaire   +2 more sources

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review [PDF]

open access: yes, 2018
Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of ...
Boas, Ulrik   +7 more
core   +4 more sources

2-Oxo-2H-chromen-3-yl 4-tert-butylbenzoate

open access: yesIUCrData, 2016
In the title coumarin derivative, C20H18O4, the benzene ring of the benzoate group is oriented at a dihedral angle of 57.55 (9)° with respect to the planar chromene ring system [maximum deviation from plane is 0.027 (2) Å].
Konan René Kambo   +4 more
doaj   +1 more source

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