Results 71 to 80 of about 12,034 (219)

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

Online and Mobile Application Diet Information for Food Chemical Intolerances: An Evaluation of the Content, Quality and Health Literacy Demand

Journal of Human Nutrition and Dietetics, Volume 39, Issue 1, February 2026.
ABSTRACT Aims To quantify the content, understandability, actionability, readability, and overall quality of food chemical intolerance dietary information for patients available online and via mobile applications. Methods Content analysis was undertaken between August 2023 and August 2024 of eligible webpages and mobile applications.
Annabel K. Clancy, Kirsty Leray, Neelam Pun   +2 more
wiley   +1 more source

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay, Sajin Marcus Cyr, Yorihiro Iwasaki, Elizabeth Hill, Eugene P. Rhee, Nevil J. Singh, Petra Simic, Murat Bastepe   +7 more
wiley   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Comprehensive Review on the Occurrence of Aflatoxin M1 in Milk, Prevalent Health Issues Associated With It, and Innovative Strategies for Mitigation of Aflatoxin M1 in Processed Milk

Food Safety and Health, Volume 4, Issue 1, Page 67-81, January 2026.
Aflatoxins, carcinogenic compounds in milk; reduction strategies such as thermal deactivation, UV light exposure, ionizing radiation, and solvent extraction. ABSTRACT Aflatoxins (AFs) are known to be cancer causing substances recognized within milk along with the milk goods.
Akshay Ramani, Tanmay Hazra, Anamika Das, Subhadip Manik, Ayon Tarafdar, Swarnima Dey, Umesh Singh   +6 more
wiley   +1 more source

Biochemical Characterization of a Disaccharidase From Enterococcus faecalis CTB

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study explores GenA, a novel disaccharidase from Enterococcus faecalis. Cloned/expressed in Escherichia coli and 98% purified, GenA hydrolyzes maltose (optimal), cellobiose, lactose, with substrate‐dependent optimal T/pH. MgCl2 boosts activity; NiCl2/MnCl2 inhibit. It aids catalytic mechanism studies and industrial biocatalysis.
Yaping Yan, Yajie Li, Wanyi Wang, Wenhui Li, Jing Yang, Xiaodong Han, Zhanying Liu   +6 more
wiley   +1 more source

Improved accuracy of lactose tolerance test in children, using expired H2 measurement. [PDF]

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A. C. Douwes, J. Fernandes, H.J. Degenhart   +2 more
openalex   +1 more source

Mitigation of Metabolic Diseases Through Personalized Nutrition: A Critical In‐Depth Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The main objective of this review is to explore the impact of variation within the microbiome and among genes on nutrient metabolism and argue in favor of successful evidence of individualized dietary intervention for cardiovascular disease, diabetes, and obesity.
Muhammad Tayyab Arshad, M. K. M. Ali, Farhang Hameed Awlqadr, Sammra Maqsood, Ali Ikram, Md. Sakhawot Hossain, Muhammed Adem Abdullahi, M. M. Rashed   +7 more
wiley   +1 more source

Tranexamic Acid for Acute Upper Respiratory Tract Infection‐Associated Sore Throat Pain: A Randomized Controlled Trial

Journal of General and Family Medicine, Volume 27, Issue 1, January 2026.
ABSTRACT Background Tranexamic acid (TXA) is sometimes used to relieve sore throat discomfort from acute upper‐respiratory tract infection (URTI), but its clinical effect has not been demonstrated in robust randomized controlled trials. Methods The tranexamic acid for URTI study is a randomized double‐blinded clinical trial that was conducted between ...
Naoto Ishimaru, Toshio Shimokawa, Masataka Ono, Shimpei Mizuki, Yohei Kanzawa, Takahiro Nakajima   +5 more
wiley   +1 more source

Retrospective Case Series of Fulminant Metabolic Crisis in GSDIA: Persistent Lactic Acidosis Despite Correction of Hypoglycemia May Reflect Secondary Mitochondrial Dysfunction

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Although several advances in glycogen storage disorder (GSD) management have been made over the years, there is still increased morbidity and mortality in these patients, particularly among those with GSD type I (GSDI). Here, we describe a case series of five patients with GSDIa who presented with severe lactic acidosis and passed away without
Herodes Guzman, Nicole Stewart, Lauren Mitteer, Victoria Sanders, Rebecca Ganetzky, Diva D. De Leon   +5 more
wiley   +1 more source