Results 201 to 210 of about 7,301 (235)

SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer

The Prostate, 2022
Prostate cancer (PCa) is an age‐related malignancy with a high incidence and mortality rate due to lack of efficacy drugs for its therapy in late castration‐resistant stage.
Rui Lin, Yiping Yang, Eran Wu, Menghan Zhou, Shan Wang, Qingyun Zhang   +5 more
semanticscholar   +1 more source

Lipidomics analysis of monocytes from patients with acute myocardial infarction reveals lactosylceramide as a new player in monocyte migration

The FASEB Journal, 2021
Monocyte recruitment after vascular injury and their migration through the vessel wall represent crucial events in the initiation, progression, and destabilization of atherosclerotic plaque.
S. Fiorelli, A. Anesi, B. Porro, N. Cosentino, J. Werba, A. Di Minno, C. Manega, Simone Barbieri, G. Colombo, G. Marenzi, V. Cavalca, E. Tremoli, S. Eligini   +12 more
semanticscholar   +1 more source

Synthesis of fluorescent lactosylceramide stereoisomers

Chemistry and Physics of Lipids, 2006
The intracellular distribution of synthetic glycosphingolipids (GSLs) bearing a fluorophore can be monitored in living cells by fluorescence microscopy. We reported previously that variation in the length of the long-chain base and in the structure of the carbohydrate-containing polar head group of (2S,3R) (or D-erythro-)-beta-lactosylceramide (LacCer)
Yidong, Liu, Robert, Bittman
openaire   +2 more sources

Lactosylceramidosis: Lactosylceramide galactosyl hydrolase deficiency and accumulation of lactosylceramide in cultured skin fibroblasts

The Journal of Pediatrics, 1971
Fibroblasts were cultured from skin and bone marrow of a patient with an unusual neurovisceral lipid storage disease, characterized by the accumulation of lactosylceramide and a deficiency of lactosylceramide galactosyl hydrolase. The fibroblasts were found to manifest the defect both chemically and enzymically.
G, Dawson, R, Matalon, A O, Stein
openaire   +2 more sources

Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.

Biochemical and Biophysical Research Communications - BBRC, 2019
Little is known about an oncogenic signal transducer β-1,4-galactosyltransferase-V (β-1,4-GalT-V), in human colorectal cancer. Using quantitative RT-PCR, immunohistochemical staining and ELISA assays, we determined that β-1,4-GalT-V gene/protein ...
S. Chatterjee, J. Hou, V. Bandaru, Maryam K. Pezhouh, Abul Ala Syed Rifat Mannan, Rajni B. Sharma   +5 more
semanticscholar   +1 more source

Synthesis of double-labeled lactosylceramide

Glycoconjugate Journal, 1986
The total stereo-controlled synthesis of lactosylceramide and introduction of two kinds of isotopes,3H and14C, into synthetic lactosylceramide are described.
Kimihiro Kanemitsu, Charles C Sweeley
openaire   +1 more source

UDP-Gal: Lactosylceramide Alpha 1,4-Galactosyltransferase (A4GALT)

2014
Koichi Furukawa, Yuji Kondo, Keiko Furukawa   +2 more
openaire   +2 more sources

Lactosylceramide: a lipid second messenger in neuroinflammatory disease

Journal of Neurochemistry, 2007
AbstractInflammatory disease plays a critical role in the pathogenesis of many neurological disorders. Astrogliosis and induction of pro‐inflammatory mediators such as chemokines, cytokines and inducible nitric oxide synthase (iNOS) are the ‘hallmarks’ of inflammatory disease.
Je-Seong, Won, Avtar K, Singh, Inderjit, Singh   +2 more
openaire   +2 more sources

Lactosylceramide is required in apoptosis induced by N-Smase

Glycoconjugate Journal, 2006
Lactosylceramide (LacCer) is a member of the glycosphingolipid family which has been recently recognized as a signaling intermediate in the regulation of cell proliferation and cell adhesion. In this paper, we present our studies pointing to a potential role of LacCer in inducing apoptosis.
Sergio F, Martin, Niesha, Williams, Subroto, Chatterjee   +2 more
openaire   +2 more sources

Targeting of lactosylceramide-containing liposomes to hepatocytes in vivo

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1983
Incorporation of 8 mol% lactosylceramide in small unilamellar vesicles consisting of cholesterol, dimyristoylphosphatidylcholine and phosphatidylserine in a molar ratio of 5:4:1 and containing [3H]inulin as an aqueous-space marker resulted in a 3-fold decreased half-life of the vesicles in blood and a corresponding increase in liver uptake after ...
Spanjer, H.H., Scherphof, G.L.
openaire   +2 more sources