Results 211 to 220 of about 7,301 (235)

The Glycosphingolipid, Lactosylceramide, Regulates β1-Integrin Clustering and Endocytosis

Cancer Research, 2005
Abstract Glycosphingolipids are known to play roles in integrin-mediated cell adhesion and migration; however, the mechanisms by which glycosphingolipids affect integrins are unknown. Here, we show that addition of the glycosphingolipid, C8-lactosylceramide (C8-LacCer), or free cholesterol to human fibroblasts at 10°C causes the ...
Deepak K, Sharma, Jennifer C, Brown, Zhijie, Cheng, Eileen L, Holicky, David L, Marks, Richard E, Pagano   +5 more
openaire   +2 more sources

Partial Purification and Properties of Porcine Thymus Lactosylceramide β-Galactosidase

The Journal of Biochemistry, 1976
Porcine thymus lactosylceramide beta-galactosidase was purified by a simple procedure. In the final step of isoelectric focusing the enzyme was separated into two peaks of pI 6.3 (peak I) and 7.0 (peak II), which showed 3,600- and 4,000-fold enhancement of lactosylceramide-hydrolysing activity, respectively.
K, Nishimura, R, Amano
openaire   +2 more sources

Lactosylceramide-enriched microdomains mediate human neutrophil immunological functions via carbohydrate-carbohydrate interaction

Glycoconjugate Journal, 2022
K. Iwabuchi, H. Nakayama, K. Hanafusa
semanticscholar   +1 more source

Lactosylceramide in lysosomal storage disorders. A comparative immunohistochemical and biochemical study

Virchows Archiv, 2005
Immunohistochemical studies of the presence of lactosylceramide (LacCer) in lysosomal storage disorders (LSDs) were done using anti-LacCer monoclonal antibody of the CDw 17 type (clone MG-2). No sign of an association between LacCer and the lysosomal system in normal cells was observed, except for histiocytes active in phagocytosis. A comparative study
H, Hůlková, J, Ledvinová, B, Asfaw, K, Koubek, K, Kopriva, M, Elleder   +5 more
openaire   +2 more sources

cDNA cloning and expression of human lactosylceramide synthase.

Biochimica et biophysica acta, 1999
Lactosylceramide synthase is an enzyme that catalyzes the transfer of galactose from UDP-Gal to glucosylceramide, and thus participates in the biosynthesis of most glycolipids in mammals. We have isolated and sequenced the cDNA clone encoding human lactosylceramide synthase.
M, Takizawa, T, Nomura, E, Wakisaka, N, Yoshizuka, J, Aoki, H, Arai, K, Inoue, M, Hattori, N, Matsuo   +8 more
openaire   +1 more source

Separation and Analysis of Lactosylceramide, Galabiosylceramide, and Globotriaosylceramide by LC-MS/MS in Urine of Fabry Disease Patients.

Analytical Chemistry, 2017
M. Boutin, Iskren Menkovic, Tristan Martineau, Vanessa Vaillancourt-Lavigueur, Amanda Toupin, C. Auray-Blais   +5 more
semanticscholar   +1 more source

Lactosylceramide‐Induced Phosphorylation Signaling to Group IVA Phospholipase A2 via Reactive Oxygen Species in Tumor Necrosis Factor‐α‐Treated Cells

Journal of Cellular Biochemistry, 2017
Hiroyuki Nakamura, Yuta Moriyama, Kazuaki Watanabe, Satoshi Tomizawa, Risa Yamazaki, Hiromasa Takahashi, T. Murayama   +6 more
semanticscholar   +1 more source

Lactosylceramide alpha-2,3-sialyltransferase

1996
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Lipoarabinomannan binding to lactosylceramide in lipid rafts is essential for the phagocytosis of mycobacteria by human neutrophils

Science Signaling, 2016
H. Nakayama, H. Kurihara, Y. Morita, T. Kinoshita, L. Mauri, A. Prinetti, S. Sonnino, N. Yokoyama, H. Ogawa, K. Takamori, K. Iwabuchi   +10 more
semanticscholar   +1 more source

Lactosylceramide beta-1,3-galactosyltransferase

1996
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source