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EXPRESS: Primary Portal Vein Hypoplasia in Cats: Clinical Findings, Diagnosis, and Outcomes in Five Cases. [PDF]

J Feline Med Surg
Bent N, Kearns S, Mouser P, Ewing P.
europepmc   +1 more source

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Lactulose therapy for patients with cirrhosis, portal hypertension, and poor patient-reported outcomes: The Mi-Kristal trial

Hepatology, 2023
Background and Aims: Poor patient-reported outcomes (PROs) are common in cirrhosis, including poor sleep and health-related quality of life (HRQOL). HE is a major driver of poor PROs. Many clinicians initiate lactulose therapy to address poor PROs.
E. Tapper, Erin Ospina, Najat Salim, Xi Chen, Samantha Nikirk   +4 more
semanticscholar   +1 more source

Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer's Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways.

Journal of Agricultural and Food Chemistry, 2021
Lactulose, as a prebiotic, can be utilized by human gut microbiota and stimulate their growth. Although microbiota modulation has become an emerging approach to manage many diseases and can be achieved by the administration of prebiotics, fewer ...
Yan-Suan Lee, D. Lai, Hei-Jen Huang, G. Lee-Chen, Ching H Chang, H. Hsieh-Li, Guan-Chiun Lee   +6 more
semanticscholar   +1 more source

Lactulose

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Lactulose significantly increased the relative abundance of Bifidobacterium and Blautia in mice feces as revealed by 16S rRNA amplicon sequencing.

The Journal of the Science of Food and Agriculture, 2021
BACKGROUND Lactulose was one of the earliest identified prebiotics. In order to assess the potential risk of large intake of lactulose to the intestinal microbiota, the mice were fed a diet containing lactulose (0%, 5% and 15%, w/w) for two weeks and the
Shumao Cui, Jiayu Gu, Xuemei Liu, Dongyao Li, Bingyong Mao, Hao Zhang, Jianxin Zhao, Wei Chen   +7 more
semanticscholar   +1 more source

Lactulose improves cognition, quality of life, and gut microbiota in minimal hepatic encephalopathy: A multicenter, randomized controlled trial

Journal of Digestive Diseases, 2019
Lactulose is effective in the treatment and prevention of overt hepatic encephalopathy (OHE), but there are limited data on its use on microbiota in relations to minimal hepatic encephalopathy (MHE) recovery.
Ji Yao Wang, J. Bajaj, Jiang-bin Wang, J. Shang, Xinping Zhou, Xiao-lin Guo, Xuan Zhu, L. Meng, Hai-xing Jiang, Y. Mi, Jian-ming Xu, J. Yang, Bai-Song Wang, Ning-ping Zhang   +13 more
semanticscholar   +1 more source

Combined PEG3350 Plus Lactulose Results in Early Resolution of Hepatic Encephalopathy and Improved 28-Day Survival in Acute-on-Chronic Liver Failure

Journal of Clinical Gastroenterology, 2020
Supplemental Digital Content is available in the text. Background and Aims: Acute-on-chronic liver failure (ACLF) is associated with high short-term mortality in those with hepatic encephalopathy (HE).
Syed Ahmed, M. Premkumar, R. Dhiman, A. Kulkarni, Rather Imran, A. Duseja, P. Kaur, S. Taneja, Virendra Singh, Saurabh Mishra, Akash Roy, R. Mehtani   +11 more
semanticscholar   +1 more source

Targeting the Gut Microbiota to Investigate the Mechanism of Lactulose in Negating the Effects of a High-Salt Diet on Hypertension.

Molecular Nutrition & Food Research, 2019
SCOPE High-salt diets (HSDs) are widely considered to cause health problems such as gut microecological imbalances, constipation, and hypertension. This study explores how lactulose as a safe molecule can stimulate bodily responses to alleviate salt ...
Zheng Zhang, Jiangtao Zhao, C. Tian, Xiao Chen, Huan Li, Xiao Wei, Weishi Lin, Naxin Zheng, Aimin Jiang, R. Feng, Jing Yuan, Xiangna Zhao   +11 more
semanticscholar   +1 more source