Results 61 to 70 of about 560,842 (308)

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Long‐Term Lake Ice Evolution in a Large Endorheic Lake Undergoing Accelerated Shrinkage in a Semiarid Region of China

Water Resources Research
Long‐term lake ice evolution under climate change has attracted global attention. However, despite the widespread occurrence of lake shrinkage in endorheic regions worldwide, few studies have explicitly addressed its effects on lake ice regimes.
Tingfeng Wu, Anning Huang, Qi Zhang, Justin Brookes, Wenming Yan, Boqiang Qin, Dequan Han, Xiaofei Hu   +7 more
doaj   +1 more source

Variability of the Lake Onega ice coverage in the period 2000-2018 according to the satellite data

Лëд и снег, 2018
Studying of characteristics of the Lake Onega ice regime and investigating of the climate influence on the formation and destruction of the ice cover requires a continuous chronological series of data on the Lake ice coverage.
V. N. Baklagin
doaj   +1 more source

Catastrophic ice lake collapse in Aram Chaos, Mars

, 2014
Hesperian chaotic terrains have been recognized as the source of outflow channels formed by catastrophic outflows. Four main scenarios have been proposed for the formation of chaotic terrains that involve different amounts of water and single or multiple
Kleinhans, Maarten G., Oosthoek, Jelmer H. P., Roda, Manuel, Zegers, Tanja E.   +3 more
core   +1 more source

Snow and ice on Bear Lake (Alaska) – sensitivity experiments with two lake ice models

Tellus A: Dynamic Meteorology and Oceanography, 2012
Snow and ice thermodynamics of Bear Lake (Alaska) are investigated with a simple freshwater lake model (FLake) and a more complex snow and ice thermodynamic model (HIGHTSI). A number of sensitivity experiments have been carried out to investigate the influence of snow and ice parameters and of different complexity on the results. Simulation results are
Semmler, T., Cheng, B., Yang, Y., Rontu, L.   +3 more
openaire   +4 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Climatic control on the peak discharge of glacier outburst floods

, 2007
Lakes impounded by natural ice dams occur in many glacier regions. Their sudden emptying along subglacial paths can unleash similar to 1 km(3) of floodwater, but predicting the peak discharge of these subglacial outburst floods ('jokulhlaups') is ...
Liu, S., Mavlyudov, B., Ng, F.S.L., Wang, Y.   +3 more
core   +1 more source

Hazard assessment of glacial lake outburst floods from Kyagar glacier, Karakoram mountains, China [PDF]

, 2014
Kyagar glacier is located in the Chinese Karakoram mountains. The glacier tongue entirely blocks the riverbed in the upper Shaksgam valley and impounds a glacial lake, which was the source of several violent and disastrous glacial lake outburst floods ...
Ao, Zhigang, Haemmig, Christoph, Hess, Josef, Huss, Matthias, Keusen, Hansrudolf, Kulubayi, Wubuli, Wegmüller, Urs   +6 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Eastern Beringia and beyond: Late Wisconsinan and Holocene landscape dynamics along the Yukon Coastal Plain, Canada [PDF]

, 2012
Terrestrial permafrost archives along the Yukon Coastal Plain (northwest Canada) have recorded landscape development and environmental change since the Late Wisconsinan at the interface of unglaciated Beringia (i.e.
Fritz, Michael, Lantuit, Hugues, Meyer, Hanno, Pollard, W. H., Preusser, F., Schirrmeister, Lutz, Wetterich, Sebastian   +6 more
core   +1 more source